Biomechanical control of lymphatic vessel physiology and functions.
biomechanical force
human diseases
lymphatic vessel
mechanosensing
mechanotransduction
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
15
02
2023
accepted:
29
04
2023
revised:
26
04
2023
medline:
1
9
2023
pubmed:
2
6
2023
entrez:
1
6
2023
Statut:
ppublish
Résumé
The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as key players that maintain human health through their functional roles in tissue fluid homeostasis, immunosurveillance, lipid metabolism and inflammation. It is therefore not surprising that the list of human diseases associated with lymphatic malfunctions has grown larger, including issues beyond lymphedema, a pathology traditionally associated with lymphatic drainage insufficiency. Thus, the discovery of factors and pathways that can promote optimal lymphatic functions may offer new therapeutic options. Accumulating evidence indicates that aside from biochemical factors, biomechanical signals also regulate lymphatic vessel expansion and functions postnatally. Here, we review how mechanical forces induced by fluid shear stress affect the behavior and functions of lymphatic vessels and the mechanisms lymphatic vessels employ to sense and transduce these mechanical cues into biological signals.
Identifiants
pubmed: 37264249
doi: 10.1038/s41423-023-01042-9
pii: 10.1038/s41423-023-01042-9
pmc: PMC10469203
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1051-1062Informations de copyright
© 2023. The Author(s), under exclusive licence to CSI and USTC.
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