Assessment of glutathione peroxidase enzyme response and total antioxidant status in oral cancer - Systematic review and meta-analysis.

Humans Antioxidants Glutathione Peroxidase Mouth Neoplasms
glutathione peroxidase activity oral cancer oral squamous cell carcinoma total antioxidant status

Journal

Cancer reports (Hoboken, N.J.)
ISSN: 2573-8348
Titre abrégé: Cancer Rep (Hoboken)
Pays: United States
ID NLM: 101747728

Informations de publication

Date de publication:
08 2023
Historique:
revised: 14 05 2023
received: 19 02 2023
accepted: 22 05 2023
medline: 18 8 2023
pubmed: 2 6 2023
entrez: 2 6 2023
Statut: ppublish

Résumé

Oxidative stress induced by free radical accumulation contributes to many pathologies, including cancer. Antioxidant defense system fails to scavenge free radicals when it is excessively accumulated. Assessing individual antioxidant enzymes and total antioxidant capacity could direct the customized therapeutic strategies. Evaluation of total antioxidant status and enzyme glutathione peroxidase activity in the oral cancer group compared to the healthy control group. The literature search included databases PubMed, Science Direct, Wiley Online Library, Cochrane and Cross Reference between 1999 and 2021. The database search was completed in the month of August 2022. The extracted data were analyzed by Comprehensive Meta-Analysis (CMA) version 3 software (Biostat Inc. Englewood, NJ). Based on search strategies, 1435 articles have been retrieved from the database. In the segregated articles, 1365 were excluded due to duplicated articles, animal studies, low-quality studies, articles unrelated to the research question, and with unmatched objectives. Based on inclusion criteria, 70 articles were selected for full-text valuation. However, 33 articles were found highly suitable for inclusion and data extraction. Finally, 11 articles were selected for meta-analysis. The meta-analysis of four included studies of tissue samples showed a significantly (p < .001) increased GPx activity in the oral cancer group, when compared to the control group, whereas three included studies of erythrocyte samples displayed a significantly (p < .001) decreased GPx activity in the oral cancer group than the control group with the pooled standardized mean difference value of -2.766 moles/min/g Hb at 95% CI (-3.297 to -2.234). The meta-analysis of the included studies depicted an insignificant (p = .947) reduction of salivary TAS levels in the oral cancer group when compared to the control group. Our systematic review and meta-analysis depict antioxidant GPx enzyme activity in the regional tissue samples of the oral cancer group differs from other systemic biological fluid samples compared to the healthy control group.

Sections du résumé

BACKGROUND
Oxidative stress induced by free radical accumulation contributes to many pathologies, including cancer. Antioxidant defense system fails to scavenge free radicals when it is excessively accumulated. Assessing individual antioxidant enzymes and total antioxidant capacity could direct the customized therapeutic strategies.
OBJECTIVE
Evaluation of total antioxidant status and enzyme glutathione peroxidase activity in the oral cancer group compared to the healthy control group.
METHOD
The literature search included databases PubMed, Science Direct, Wiley Online Library, Cochrane and Cross Reference between 1999 and 2021. The database search was completed in the month of August 2022. The extracted data were analyzed by Comprehensive Meta-Analysis (CMA) version 3 software (Biostat Inc. Englewood, NJ). Based on search strategies, 1435 articles have been retrieved from the database. In the segregated articles, 1365 were excluded due to duplicated articles, animal studies, low-quality studies, articles unrelated to the research question, and with unmatched objectives. Based on inclusion criteria, 70 articles were selected for full-text valuation. However, 33 articles were found highly suitable for inclusion and data extraction. Finally, 11 articles were selected for meta-analysis.
RESULTS
The meta-analysis of four included studies of tissue samples showed a significantly (p < .001) increased GPx activity in the oral cancer group, when compared to the control group, whereas three included studies of erythrocyte samples displayed a significantly (p < .001) decreased GPx activity in the oral cancer group than the control group with the pooled standardized mean difference value of -2.766 moles/min/g Hb at 95% CI (-3.297 to -2.234). The meta-analysis of the included studies depicted an insignificant (p = .947) reduction of salivary TAS levels in the oral cancer group when compared to the control group.
CONCLUSION
Our systematic review and meta-analysis depict antioxidant GPx enzyme activity in the regional tissue samples of the oral cancer group differs from other systemic biological fluid samples compared to the healthy control group.

Identifiants

DOI: 10.1002/cnr2.1842 PMID: 37265029 PMC: PMC10432471
pubmed: 37265029
doi: 10.1002/cnr2.1842
pmc: PMC10432471
doi:

Substances chimiques

Antioxidants 0
Glutathione Peroxidase EC 1.11.1.9

Types de publication

Meta-Analysis Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1842

Informations de copyright

© 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.

Références

J Oral Pathol Med. 2002 Feb;31(2):71-7
pubmed: 11896826
J Cancer Res Ther. 2010 Jan-Mar;6(1):47-53
pubmed: 20479547
Asian Pac J Cancer Prev. 2012;13(9):4409-12
pubmed: 23167351
Chem Biol Interact. 2006 Mar 10;160(1):1-40
pubmed: 16430879
Cancer Rep (Hoboken). 2023 Aug;6(8):e1842
pubmed: 37265029
Dent Res J (Isfahan). 2012 Mar;9(2):158-61
pubmed: 22623931
J Clin Diagn Res. 2017 Mar;11(3):BC01-BC05
pubmed: 28511368
Contemp Clin Dent. 2012 Jul;3(3):271-6
pubmed: 23293480
J Lab Clin Med. 1963 May;61:882-8
pubmed: 13967893
Cancer Biomark. 2009;5(6):253-60
pubmed: 20037201
Blood. 1959 Feb;14(2):103-39
pubmed: 13618370
Oral Dis. 2010 Jan;16(1):29-33
pubmed: 19656315
Head Neck. 2011 Nov;33(11):1606-15
pubmed: 21990225
Arch Oral Biol. 2016 Oct;70:62-66
pubmed: 27328152
Kathmandu Univ Med J (KUMJ). 2005 Oct-Dec;3(4):334-9
pubmed: 16449831
Acta Odontol Scand. 2019 Aug;77(6):408-418
pubmed: 30857448
Oral Oncol. 2014 Jan;50(1):10-8
pubmed: 24126222
Br J Oral Maxillofac Surg. 2000 Aug;38(4):267-70
pubmed: 10922148
J Lab Clin Med. 1967 Jul;70(1):158-69
pubmed: 6066618
Saudi J Biol Sci. 2021 Dec;28(12):6987-6991
pubmed: 34866998
Cell Biochem Funct. 1999 Sep;17(3):213-6
pubmed: 10451543
J Oral Maxillofac Pathol. 2019 Sep-Dec;23(3):450-457
pubmed: 31942130
Free Radic Biol Med. 2007 May 15;42(10):1465-9
pubmed: 17448892
J Oral Pathol Med. 2012 Nov;41(10):736-40
pubmed: 22582895
Cancer Res. 1994 Apr 1;54(7 Suppl):1969s-1975s
pubmed: 8137322
Toxicol Mech Methods. 2003;13(1):77-81
pubmed: 20021184
Clin Chim Acta. 2006 Nov;373(1-2):92-8
pubmed: 16831410
J Oral Pathol Med. 2016 Nov;45(10):753-757
pubmed: 26876359
PLoS One. 2013 Nov 04;8(11):e80229
pubmed: 24224046
Cancer. 1980 Jun 15;45(12):2940-8
pubmed: 7388737
Jpn J Clin Oncol. 2004 Jul;34(7):379-85
pubmed: 15342664
Clin Biochem. 2002 Sep;35(6):489-93
pubmed: 12413611
Indian J Cancer. 1986 Mar;23(1):36-42
pubmed: 3817860
Biochem Soc Trans. 2007 Nov;35(Pt 5):1147-50
pubmed: 17956298
Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1190-5
pubmed: 11451750
Cancer. 2007 Jan 1;109(1):54-9
pubmed: 17099862
J Clin Exp Dent. 2017 Jan 1;9(1):e71-e77
pubmed: 28149467
Science. 1973 Feb 9;179(4073):588-90
pubmed: 4686466
J Cancer Res Ther. 2010 Oct-Dec;6(4):487-91
pubmed: 21358086
J Oral Maxillofac Pathol. 2018 Sep-Dec;22(3):447
pubmed: 30651704
J Int Soc Prev Community Dent. 2016 Dec;6(Suppl 3):S213-S218
pubmed: 28217539
Free Radic Res. 2016;50(2):126-42
pubmed: 26291534
Indian J Med Res. 2005 Dec;122(6):529-34
pubmed: 16518005
Oxid Med Cell Longev. 2013;2013:972913
pubmed: 23766865
Biochem Biophys Res Commun. 1976 Aug 23;71(4):952-8
pubmed: 971321
Indian J Cancer. 2012 Jul-Sep;49(3):309-15
pubmed: 23238150
J Surg Oncol. 2007 Sep 1;96(3):194-9
pubmed: 17443722
Eur Rev Med Pharmacol Sci. 2005 Nov-Dec;9(6):361-7
pubmed: 16479741
Pharmacognosy Res. 2015 Apr-Jun;7(2):184-7
pubmed: 25829792
Indian J Clin Biochem. 2018 Jul;33(3):348-355
pubmed: 30072836
Oncology. 2011;80(5-6):382-9
pubmed: 21829039
Am J Med. 2000 Jun 1;108(8):652-9
pubmed: 10856414

Auteurs

Khadijah Mohideen (K)

Department of Oral Pathology and Microbiology, Sathyabama Dental College and Hospital, Sathyabama Institute of Science and Technology, Chennai, India.

Nadeem Jeddy (N)

Department of Oral Pathology and Microbiology, Thai Moogambigai Dental College and Hospital, Dr. M.G.R. Educational and Research Institute, Chennai, India.

C Krithika (C)

Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.

Shahul Hameed Faizee (SH)

Department of Orthodontics and Dentofacial Orthopaedics, Sathyabama Dental College and Hospital, Sathyabama Institute of Science and Technology, Chennai, India.

Safal Dhungel (S)

Department of Oral and Maxillofacial Surgery, College of Medical Sciences, Bharatpur, Nepal.

Snehashish Ghosh (S)

Department of Oral Pathology, College of Medical Sciences, Bharatpur, Nepal.
ORCID: 0000-0002-7349-1619

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Assessment of glutathione peroxidase enzyme...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Assessment of glutathione peroxidase enzyme...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sélénoprotéines › Glutathione peroxidase › Assessment of glutathione peroxidase enzyme...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Tumeurs de la bouche › Assessment of glutathione peroxidase enzyme...