Updating germ cell tumour pathogenesis - the ability of seminomas for FOXA2-driven extra-embryonic differentiation.
FOXA2
differentiation
germ cell tumours
seminoma
yolk-sac tumour
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
revised:
06
04
2023
received:
03
03
2023
accepted:
16
04
2023
medline:
11
8
2023
pubmed:
2
6
2023
entrez:
2
6
2023
Statut:
ppublish
Résumé
Testicular germ cell tumours are the most common solid malignancies in young men of age 14-44 years. It is generally accepted that both seminomas and non-seminomas arise from a common precursor, the germ cell neoplasia in-situ, which itself is the result of a defective (primordial) germ cell development. The stem cell-like population of the non-seminomas, the embryonal carcinoma, is capable of the differentiation of all three germ layers (teratomas) and extra-embryonic tissues (yolk-sac tumours, choriocarcioma) into cells. In contrast, seminomas are thought to have a limited differentiation potential. Nevertheless, several studies have highlighted their ability to undergo reprogramming to an embryonal carcinoma or differentiation into other non-seminomatous entities. Here, we demonstrate that in approximately 5% of seminomas, the yolk-sac tumour driver gene FOXA2 is detectable at the protein level, indicative of an occult yolk-sac tumour subpopulation that putatively arose from seminoma cells, as the presence of other GCT entities could be excluded. The presence of these subpopulations might render the tumour more aggressive and argue for an adjustment of the therapeutic concept. We used our data to update the model of germ cell tumour pathogenesis, especially regarding the developmental potential of seminomas. Additionally, we suggest to include detection of FOXA2 into standard routine diagnosis of seminomas.
Substances chimiques
FOXA2 protein, human
0
Hepatocyte Nuclear Factor 3-beta
135845-92-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
477-481Subventions
Organisme : Wilhelm Sander-Stiftung
ID : 2016.041.3
Organisme : Wilhelm Sander-Stiftung
ID : 2016.041.2
Organisme : Wilhelm Sander-Stiftung
ID : 2016.041.1
Informations de copyright
© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.
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