Type 2 inflammation and biological therapies in asthma: Targeted medicine taking flight.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
03 07 2023
03 07 2023
Historique:
received:
09
11
2022
revised:
16
02
2023
accepted:
12
05
2023
medline:
5
6
2023
pubmed:
2
6
2023
entrez:
2
6
2023
Statut:
ppublish
Résumé
The field of asthma has undergone a dramatic change in recent years. Advances in our understanding of type 2 airway inflammation have driven the discovery of monoclonal antibodies targeting specific aspects of the immune pathway. In landmark trials, these drugs have shown efficacy in reducing asthma attacks and exposure to oral corticosteroids, important causes of morbidity in people with asthma. Our review explores the key features of type 2 inflammation in asthma and summarizes the clinical trial evidence of the novel monoclonal antibody treatments and future avenues for treatment.
Identifiants
pubmed: 37265457
pii: 214160
doi: 10.1084/jem.20221212
pmc: PMC10239209
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2023 Howell et al.
Références
J Allergy Clin Immunol. 2021 Sep;148(3):790-798
pubmed: 33872652
N Engl J Med. 2018 Jun 28;378(26):2475-2485
pubmed: 29782224
Lancet Respir Med. 2022 Jan;10(1):11-25
pubmed: 34597534
Respirology. 2022 Aug;27(8):573-577
pubmed: 35591794
Respir Res. 2020 Oct 13;21(1):264
pubmed: 33050928
Nat Immunol. 2015 Feb;16(2):161-9
pubmed: 25531830
J Exp Med. 1994 Apr 1;179(4):1145-54
pubmed: 7511681
Am J Respir Crit Care Med. 2019 Jun 15;199(12):1471-1477
pubmed: 30645143
J Exp Med. 1995 Oct 1;182(4):1169-74
pubmed: 7561691
Clin Exp Allergy. 2017 Feb;47(2):148-160
pubmed: 28134501
N Engl J Med. 2017 Jun 22;376(25):2448-2458
pubmed: 28530840
Pharmaceutics. 2022 Dec 08;14(12):
pubmed: 36559247
Mucosal Immunol. 2015 May;8(3):672-82
pubmed: 25336167
Adv Immunol. 2009;101:81-121
pubmed: 19231593
Cell Mol Immunol. 2019 Mar;16(3):225-235
pubmed: 30792500
J Allergy Clin Immunol. 2007 Jun;119(6):1303-10; quiz 1311-2
pubmed: 17481712
Respir Med. 2019 Nov - Dec;160:105819
pubmed: 31734469
J Allergy Clin Immunol. 2021 Oct;148(4):953-963
pubmed: 34625142
Lancet Respir Med. 2017 May;5(5):390-400
pubmed: 28395936
J Allergy Clin Immunol. 2017 Jul;140(1):76-88.e7
pubmed: 27746238
Nat Rev Immunol. 2015 May;15(5):271-82
pubmed: 25882242
Mucosal Immunol. 2020 Mar;13(2):283-292
pubmed: 31745261
Cell Death Dis. 2021 Aug 2;12(8):761
pubmed: 34341336
Nat Rev Immunol. 2013 Aug;13(8):607-14
pubmed: 23827958
Eur Respir J. 2023 Jan 12;61(1):
pubmed: 35953100
Respir Res. 2020 Oct 13;21(1):266
pubmed: 33050934
J Allergy Clin Immunol Pract. 2021 Mar;9(3):1121-1132.e7
pubmed: 32889223
Chest. 2017 Jun;151(6):1338-1344
pubmed: 27818325
Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000195
pubmed: 17636617
N Engl J Med. 2010 Dec 2;363(23):2233-47
pubmed: 21121836
Curr Treat Options Allergy. 2021;8(3):261-273
pubmed: 33880321
Ann Allergy Asthma Immunol. 2019 Dec;123(6):564-572.e3
pubmed: 31494235
Nat Immunol. 2004 Apr;5(4):426-34
pubmed: 14991051
Blood. 2000 May 15;95(10):3146-52
pubmed: 10807781
Cell. 2021 Apr 29;184(9):2521-2522
pubmed: 33930297
Adv Ther. 2018 May;35(5):737-748
pubmed: 29725983
J Allergy Clin Immunol. 2015 Dec;136(6):1636-1644
pubmed: 25962901
Lancet Respir Med. 2023 May;11(5):425-438
pubmed: 36702146
N Engl J Med. 2009 Mar 5;360(10):985-93
pubmed: 19264687
Nature. 2022 Apr;604(7905):337-342
pubmed: 35355021
J Med Chem. 2019 May 9;62(9):4312-4324
pubmed: 30869888
Lancet Respir Med. 2021 Aug;9(8):873-884
pubmed: 33609487
Cytokine. 2015 Sep;75(1):68-78
pubmed: 26070934
J Allergy Clin Immunol Pract. 2021 Mar;9(3):1267-1275
pubmed: 33039645
J Asthma Allergy. 2018 Aug 29;11:193-204
pubmed: 30214247
N Engl J Med. 2014 Sep 25;371(13):1198-207
pubmed: 25199059
N Engl J Med. 2017 Mar 16;376(11):1090-1
pubmed: 28296614
J Allergy Clin Immunol. 2015 Jun;135(6):1594-602
pubmed: 25656998
J Allergy Clin Immunol. 2013 Jun;131(6):1504-12
pubmed: 23506843
Eur Respir Rev. 2022 Sep 20;31(165):
pubmed: 36130784
Eur Respir J. 2016 Jan;47(1):304-19
pubmed: 26677936
J Aerosol Med Pulm Drug Deliv. 2016 Jun;29(3):233-41
pubmed: 27111445
Nat Genet. 2018 Jan;50(1):42-53
pubmed: 29273806
Eur Respir J. 2022 Mar 3;59(3):
pubmed: 34289975
J Biol Chem. 2002 Nov 8;277(45):43481-94
pubmed: 12202480
J Allergy Clin Immunol. 2020 Feb;145(2):528-536.e1
pubmed: 31145939
Lancet Respir Med. 2016 Oct;4(10):781-796
pubmed: 27616196
Ann Allergy Asthma Immunol. 2022 Apr;128(4):390-397
pubmed: 35172180
Cells. 2022 Mar 24;11(7):
pubmed: 35406669
Chest. 2012 Jul;142(1):76-85
pubmed: 22052771
Immunity. 2019 Apr 16;50(4):975-991
pubmed: 30995510
Int Immunol. 1998 Oct;10(10):1421-33
pubmed: 9796908
J Allergy Clin Immunol. 2010 Apr;125(4):844-50
pubmed: 20236697
Blood. 2018 Nov 15;132(20):2183-2187
pubmed: 30154112
J Allergy Clin Immunol. 2012 Aug;130(2):516-22.e4
pubmed: 22541248
Allergy. 2014 Aug;69(8):1068-76
pubmed: 24888572
Lancet. 2019 Nov 2;394(10209):1638-1650
pubmed: 31543428
Nat Rev Cancer. 2020 Oct;20(10):594-607
pubmed: 32678342
J Clin Invest. 2018 Mar 1;128(3):997-1009
pubmed: 29400693
N Engl J Med. 2014 Sep 25;371(13):1189-97
pubmed: 25199060
Eur Respir J. 2021 Dec 31;59(1):
pubmed: 34667060
Nat Rev Drug Discov. 2007 Apr;6(4):313-25
pubmed: 17396136
Lancet. 2012 Aug 18;380(9842):651-9
pubmed: 22901886
Cureus. 2022 May 22;14(5):e25218
pubmed: 35747049
Lancet. 1956 Oct 20;271(6947):803-6
pubmed: 13368522
Lancet Respir Med. 2015 May;3(5):355-66
pubmed: 25736990
J Allergy Clin Immunol. 2005 Oct;116(4):796-804
pubmed: 16210053
J Allergy Clin Immunol. 2007 Dec;120(6):1324-31
pubmed: 17889290
Curr Med Res Opin. 2011 Nov;27(11):2223-8
pubmed: 21933100
Immunity. 2013 Feb 21;38(2):322-35
pubmed: 23352232
J Exp Med. 2005 Nov 7;202(9):1213-23
pubmed: 16275760
Science. 2019 May 24;364(6442):
pubmed: 31123109
Am J Respir Crit Care Med. 2021 Apr 1;203(7):809-821
pubmed: 33326352
Br J Clin Pharmacol. 2018 Feb;84(2):339-348
pubmed: 29044640
Respir Res. 2016 Jan 14;17:5
pubmed: 26762527
Lancet Respir Med. 2018 Jul;6(7):511-525
pubmed: 29792288
Front Med (Lausanne). 2020 May 21;7:191
pubmed: 32509793
Allergy Asthma Clin Immunol. 2020 Jun 18;16:49
pubmed: 32565844
Lancet. 2016 Oct 29;388(10056):2115-2127
pubmed: 27609408
JAMA. 2017 Jan 17;317(3):269-279
pubmed: 28114551
Nat Med. 2012 May 04;18(5):693-704
pubmed: 22561833
J Allergy Clin Immunol. 2016 Jan;137(1):258-267
pubmed: 26070883
Immunity. 2018 Jun 19;48(6):1195-1207.e6
pubmed: 29907525
N Engl J Med. 2021 Dec 9;385(24):2230-2240
pubmed: 34879449
J Immunol. 2018 Oct 15;201(8):2221-2231
pubmed: 30185520
N Engl J Med. 2009 Mar 5;360(10):973-84
pubmed: 19264686
Eur Respir J. 2009 Aug;34(2):425-35
pubmed: 19164348
Am J Respir Crit Care Med. 2019 Feb 15;199(4):454-464
pubmed: 30339770
J Immunol. 2002 Nov 1;169(9):4788-96
pubmed: 12391188
Nat Immunol. 2019 May;20(5):637-651
pubmed: 30962590
J Exp Med. 1997 Nov 17;186(10):1737-47
pubmed: 9362533
Am J Respir Crit Care Med. 1997 Jun;155(6):1828-34
pubmed: 9196082
Blood. 2001 Sep 15;98(6):1942-8
pubmed: 11535533
Lancet. 2022 Aug 13;400(10351):502-511
pubmed: 35964610
Lancet. 2016 Oct 29;388(10056):2128-2141
pubmed: 27609406
Nature. 2022 Mar;603(7903):949-956
pubmed: 35322233
N Engl J Med. 2021 Mar 18;384(11):989-1002
pubmed: 33567185
J Leukoc Biol. 2018 Jul;104(1):61-67
pubmed: 29633324
J Leukoc Biol. 2013 Aug;94(2):213-22
pubmed: 23532518
Am J Respir Crit Care Med. 2022 May 1;205(9):1036-1045
pubmed: 35104436
Curr Mol Med. 2008 Aug;8(5):384-92
pubmed: 18691065
Am J Respir Cell Mol Biol. 2010 Sep;43(3):305-15
pubmed: 19843704
Thorax. 2003 Feb;58(2):175-82
pubmed: 12554905
Am J Respir Crit Care Med. 2021 Dec 1;204(11):1259-1273
pubmed: 34469272
J Clin Immunol. 2013 Apr;33(3):595-604
pubmed: 23180361
Allergy. 2020 Jul;75(7):1606-1617
pubmed: 31975538
N Engl J Med. 2021 Oct 28;385(18):1656-1668
pubmed: 34706171
Respir Res. 2001;2(3):150-6
pubmed: 11686879
N Engl J Med. 2020 Nov 26;383(22):2127-2137
pubmed: 32897034
Am J Respir Crit Care Med. 2020 Nov 1;202(9):1314-1316
pubmed: 32584603
J Allergy Clin Immunol. 2012 Apr;129(4):889-901
pubmed: 22464668
Clin Exp Allergy. 2018 Sep;48(9):1173-1185
pubmed: 29451337