Biological mechanisms underpinning the development of long COVID.
Health sciences
Medicine
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
medline:
2
6
2023
pubmed:
2
6
2023
entrez:
2
6
2023
Statut:
ppublish
Résumé
As COVID-19 evolves from a pandemic to an endemic disease, the already staggering number of people that have been or will be infected with SARS-CoV-2 is only destined to increase, and the majority of humanity will be infected. It is well understood that COVID-19, like many other viral infections, leaves a significant fraction of the infected with prolonged consequences. Continued high number of SARS-CoV-2 infections, viral evolution with escape from post-infection and vaccinal immunity, and reinfections heighten the potential impact of Long COVID. Hence, the impact of COVID-19 on human health will be seen for years to come until more effective vaccines and pharmaceutical treatments become available. To that effect, it is imperative that the mechanisms underlying the clinical manifestations of Long COVID be elucidated. In this article, we provide an in-depth analysis of the evidence on several potential mechanisms of Long COVID and discuss their relevance to its pathogenesis.
Identifiants
pubmed: 37265584
doi: 10.1016/j.isci.2023.106935
pii: S2589-0042(23)01012-X
pmc: PMC10193768
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
106935Subventions
Organisme : Medical Research Council
ID : MC_PC_16022
Pays : United Kingdom
Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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