Rituximab-Induced Serum Sickness Overlapping With Anaphylaxis: A Case Report.
anaphylaxis
biotherapy allergy
immune complexes
rituximab
serum sickness
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
accepted:
30
04
2023
medline:
2
6
2023
pubmed:
2
6
2023
entrez:
2
6
2023
Statut:
epublish
Résumé
Serum sickness (SS) and anaphylaxis are well-documented complications of rituximab (RTX) infusions. While the first presents usually as a triad of fever, rash, and arthralgias occurring seven to 14 days after infusion, the second presents as a sudden onset of hemodynamic instability, bronchospasm, and a pruritic erythematous rash, occurring within the first few hours after infusion. We present here a case of serum sickness associated with anaphylaxis five days after the first infusion of a second course of RTX. Only eight cases of rituximab-induced serum sickness (RISS) associated with hemodynamic instability have been reported. We describe the first case of proven anaphylaxis with an elevated tryptase serum level occurring in conjunction with RISS, six days after a third RTX infusion.
Identifiants
pubmed: 37266062
doi: 10.7759/cureus.38333
pmc: PMC10230849
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e38333Informations de copyright
Copyright © 2023, Cottu et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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