GLACIER: GLASS-BOX TRANSFORMER FOR INTERPRETABLE DYNAMIC NEUROIMAGING.

Interpretable DL fMRI neuroimaging

Journal

Proceedings of the ... IEEE International Conference on Acoustics, Speech, and Signal Processing. ICASSP (Conference)
ISSN: 1520-6149
Titre abrégé: Proc IEEE Int Conf Acoust Speech Signal Process
Pays: United States
ID NLM: 101182171

Informations de publication

Date de publication:
Jun 2023
Historique:
medline: 2 6 2023
pubmed: 2 6 2023
entrez: 2 6 2023
Statut: ppublish

Résumé

Deep learning models can perform as well or better than humans in many tasks, especially vision related. Almost exclusively, these models are used to perform classification or prediction. However, deep learning models are usually of black-box nature, and it is often difficult to interpret the model or the features. The lack of interpretability causes a restrain from applying deep learning to fields such as neuroimaging, where the results must be transparent, and interpretable. Therefore, we present a 'glass-box' deep learning model and apply it to the field of neuroimaging. Our model mixes spatial and temporal dimensions in succession to estimate dynamic connectivity between the brain's intrinsic networks. The interpretable connectivity matrices produced by our model result in beating state-of-the-art models on many tasks using multiple functional MRI datasets. More importantly, our model estimates task-based flexible connectivity matrices, unlike static methods such as Pearson's correlation coefficients.

Identifiants

pubmed: 37266485
doi: 10.1109/icassp49357.2023.10097126
pmc: PMC10231935
mid: NIHMS1889297
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIBIB NIH HHS
ID : R01 EB006841
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH129047
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH121885
Pays : United States

Références

Front Syst Neurosci. 2011 Feb 08;5:7
pubmed: 21369355
Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34
pubmed: 20471808
Alzheimers Dement. 2015 Jan;11(1):70-98
pubmed: 25022540
Brain Imaging Behav. 2019 Oct;13(5):1220-1235
pubmed: 30094555
Dev Cogn Neurosci. 2018 Aug;32:43-54
pubmed: 29567376
Neuroimage. 2017 Feb 1;146:1038-1049
pubmed: 27693612
Mol Psychiatry. 2014 Jun;19(6):659-67
pubmed: 23774715
Neuroimage. 2016 Jan 1;124(Pt B):1074-1079
pubmed: 26364863
Neuroimage. 2018 Apr 1;169:431-442
pubmed: 29278772
Arch Neurol. 1998 Mar;55(3):395-401
pubmed: 9520014
Front Neurosci. 2020 Jun 30;14:630
pubmed: 32714130
Hum Brain Mapp. 2019 Aug 1;40(11):3203-3221
pubmed: 30950567
Neuroimage Clin. 2021;29:102531
pubmed: 33340977

Auteurs

Usman Mahmood (U)

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Georgia State University, Department of Computer Science, Atlanta, GA, USA.

Zening Fu (Z)

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Georgia State University, Department of Computer Science, Atlanta, GA, USA.

Vince Calhoun (V)

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Georgia Institute of Technology, Department of Electrical and Computer Engineering, Atlanta, GA, USA.

Sergey Plis (S)

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Georgia State University, Department of Computer Science, Atlanta, GA, USA.

Classifications MeSH