Functional ultrasound detects frequency-specific acute and delayed S-ketamine effects in the healthy mouse brain.
S-ketamine
frequency bands (range)
functional connectivity
functional ultrasound (fUS)
pharmacological imaging
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
03
2023
accepted:
21
04
2023
medline:
2
6
2023
pubmed:
2
6
2023
entrez:
2
6
2023
Statut:
epublish
Résumé
S-ketamine has received great interest due to both its antidepressant effects and its potential to induce psychosis when administered subchronically. However, no studies have investigated both its acute and delayed effects using We acquired fUS in a total of 16 healthy C57/Bl6 mice split in two cohorts ( We found reproducible ( In summary, the study reports that acute and delayed ketamine effects in mice are not only dissimilar but have different directionalities in most frequency bands. The complementary readouts of the employed frequency bands recommend the use of fUS for frequency-specific investigation of pharmacological effects on FC.
Identifiants
pubmed: 37266546
doi: 10.3389/fnins.2023.1177428
pmc: PMC10229773
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1177428Informations de copyright
Copyright © 2023 Ionescu, Grohs-Metz and Hengerer.
Déclaration de conflit d'intérêts
TI, GG-M, and BH are employed by Boehringer Ingelheim Pharma GmbH & Co.
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