Effects of bone marrow-derived mesenchymal stem cell transplantation in piglet Legg-Calve-Perthes disease models: a pilot study.


Journal

Journal of pediatric orthopedics. Part B
ISSN: 1473-5865
Titre abrégé: J Pediatr Orthop B
Pays: United States
ID NLM: 9300904

Informations de publication

Date de publication:
22 May 2023
Historique:
medline: 2 6 2023
pubmed: 2 6 2023
entrez: 2 6 2023
Statut: aheadofprint

Résumé

This preliminary study investigated the efficacy and safety of bone marrow-derived mesenchymal stem cell transplantation in a piglet Legg-Calve-Perthes disease (LCPD) model. The LCPD model was induced in two Landrace piglets (6- and 7-week-old, weighing 12 and 17 kg, respectively) by ligaturing the femoral neck. In the first piglet, the natural LCPD course was observed. In the second piglet, 4 weeks after ligaturing the femoral neck, simple medium and medium containing 2.44 × 107 bone marrow-derived mesenchymal stem cells were transplanted into the right and left femoral heads after core decompression, respectively. Plain radiographs were obtained every 4 weeks, and the epiphyseal quotient was calculated by dividing the maximum epiphysis height by the maximum epiphysis diameter. The piglets were sacrificed at 14 weeks postoperatively. The femoral heads were extracted and evaluated grossly, pathologically, and by using computed tomography. The transplanted cell characteristics were evaluated using flow cytometry. Flattening of the epiphysis was observed in both femoral heads of the first piglet and only in the right hip of the second piglet. The epiphyseal quotients immediately and at 14 weeks postoperatively in the right femoral head of the second piglet were 0.40 and 0.14, respectively, while those of the left femoral head were 0.30 and 0.42, respectively. Hematoxylin and eosin staining did not reveal physeal bar or tumor cell formation. The transplanted cells were 99.2%, 65.9%, 18.2%, and 0.16% positive for CD44, CD105, CD29, and CD31, respectively. Core decompression combined with bone marrow-derived mesenchymal stem cell transplantation prevented epiphyseal collapse.

Identifiants

pubmed: 37266936
doi: 10.1097/BPB.0000000000001095
pii: 01202412-990000000-00122
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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Auteurs

Yohei Tomaru (Y)

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba.

Hisashi Sugaya (H)

Department of Orthopaedic Surgery, Tsukuba University of Technology, Tsukuba, Ibaraki.

Tomokazu Yoshioka (T)

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba.

Norihito Arai (N)

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba.

Tomoyuki Abe (T)

Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.

Yuta Tsukagoshi (Y)

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba.

Hiroshi Kamada (H)

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba.

Masashi Yamazaki (M)

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba.

Hajime Mishima (H)

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba.

Classifications MeSH