Exosome and exosomal contents in schizophrenia.

Humans Schizophrenia / metabolism Exosomes / metabolism Biomarkers / metabolism MicroRNAs / metabolism
Biomarker Exosome Omics Schizophrenia miRNA

Journal

Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331

Informations de publication

Date de publication:
07 2023
Historique:
received: 12 12 2022
revised: 06 03 2023
accepted: 25 05 2023
medline: 12 6 2023
pubmed: 3 6 2023
entrez: 2 6 2023
Statut: ppublish

Résumé

Schizophrenia (SCZ) is a severe mental disorder that affects approximately 1% general population worldwide and poses a considerable burden to society. Despite decades of research, its etiology remains unclear, and diagnosis remains challenging due to its heterogeneous symptoms. Exosomes play a crucial role in intercellular communication, and their contents, including nucleotides, proteins and metabolites, have been linked to various diseases. Recent studies have implicated exosome abnormalities in the pathogenesis of schizophrenia. In this review, we discuss the current understanding of the relationship between exosomes and schizophrenia, focusing on the role of exosomal contents in this disease. We summarize recent findings and provide insights into the potential use of exosomes as biomarkers for the diagnosis and treatment of schizophrenia.

Identifiants

DOI: 10.1016/j.jpsychires.2023.05.072 PMID: 37267733
pubmed: 37267733
pii: S0022-3956(23)00266-2
doi: 10.1016/j.jpsychires.2023.05.072
pii:
doi:

Substances chimiques

Biomarkers 0
MicroRNAs 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

365-371

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare none.

Auteurs

Tingkai Zhang (T)

Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Yehong Fang (Y)

Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Liangliang Wang (L)

Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Lin Gu (L)

RIKEN AIP, Tokyo, Japan; Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo, Japan.

Jinsong Tang (J)

Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: tangjinsong@zju.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exosome and exosomal contents in schizophrenia.
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Exosome and exosomal contents in schizophrenia.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Exosomes › Exosome and exosomal contents in schizophrenia.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Exosome and exosomal contents in schizophrenia.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Exosome and exosomal contents in schizophrenia.