Liquid-based cytology (LBC) with immunocytochemical staining improves fine-needle aspiration cytology (FNA) performance for salivary gland tumors.

Humans Biopsy, Fine-Needle / methods Retrospective Studies Salivary Gland Neoplasms / diagnosis Cytodiagnosis Staining and Labeling Sensitivity and Specificity
Fine-needle aspiration cytology (FNA) Immunocytochemical staining Liquid-based cytology (LBC) Salivary gland tumor Sensitivity Specificity

Journal

Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109

Informations de publication

Date de publication:
Aug 2023
Historique:
received: 11 04 2023
accepted: 28 05 2023
medline: 16 8 2023
pubmed: 3 6 2023
entrez: 2 6 2023
Statut: ppublish

Résumé

Liquid-based cytology (LBC), now used globally for the head and neck region, has been used at our hospital since 2011. This study was designed to analyze the efficacy of LBC with immunocytochemical staining on preoperative diagnosis of salivary gland tumors. This retrospective analysis of fine-needle aspiration (FNA) performance for salivary gland tumors was conducted at Fukui University Hospital. Salivary gland tumor operations conducted during April 2006 - December 2010 (84 cases) were classified as the Conventional Smear (CS) group, which were diagnosed morphologically by Papanicolaou and Giemsa staining. Those done during January 2012 - April 2017 (112 cases) were classified as the LBC group, which were diagnosed using LBC samples with immunocytochemical staining. The FNA results and pathological diagnosis of both groups were analyzed to calculate the FNA performance. Compared to the CS group, cases of inadequate and indeterminate FNA sample were not reduced significantly by LBC with immunocytochemical staining. As for FNA performance, the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CS group were, respectively, 88.7%, 53.3%, 100%, 100%, and 87.0%. Those of LBC group were all 100%, representing significant improvement over the CS group. Analysis results indicated the usefulness of LBC with immunocytochemical staining for preoperative diagnosis of salivary gland tumors.

Sections du résumé

BACKGROUND BACKGROUND
Liquid-based cytology (LBC), now used globally for the head and neck region, has been used at our hospital since 2011. This study was designed to analyze the efficacy of LBC with immunocytochemical staining on preoperative diagnosis of salivary gland tumors.
METHODS METHODS
This retrospective analysis of fine-needle aspiration (FNA) performance for salivary gland tumors was conducted at Fukui University Hospital. Salivary gland tumor operations conducted during April 2006 - December 2010 (84 cases) were classified as the Conventional Smear (CS) group, which were diagnosed morphologically by Papanicolaou and Giemsa staining. Those done during January 2012 - April 2017 (112 cases) were classified as the LBC group, which were diagnosed using LBC samples with immunocytochemical staining. The FNA results and pathological diagnosis of both groups were analyzed to calculate the FNA performance.
RESULTS RESULTS
Compared to the CS group, cases of inadequate and indeterminate FNA sample were not reduced significantly by LBC with immunocytochemical staining. As for FNA performance, the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CS group were, respectively, 88.7%, 53.3%, 100%, 100%, and 87.0%. Those of LBC group were all 100%, representing significant improvement over the CS group.
CONCLUSIONS CONCLUSIONS
Analysis results indicated the usefulness of LBC with immunocytochemical staining for preoperative diagnosis of salivary gland tumors.

Identifiants

DOI: 10.1016/j.prp.2023.154582 PMID: 37267770
pubmed: 37267770
pii: S0344-0338(23)00282-0
doi: 10.1016/j.prp.2023.154582
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

154582

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Norihiko Narita reports a relationship with University of Fukui Faculty of Medical Sciences that includes: employment.

Auteurs

Junya Kimura (J)

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan; Division of Diagnostic Pathology / Surgical Pathology, University of Fukui Hospital, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Norihiko Narita (N)

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan. Electronic address: norihiko@u-fukui.ac.jp.

Yoshiaki Imamura (Y)

Division of Diagnostic Pathology / Surgical Pathology, University of Fukui Hospital, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Takahiro Tokunaga (T)

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Masaki Mori (M)

Division of Diagnostic Pathology / Surgical Pathology, University of Fukui Hospital, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Haruka Matsukawa (H)

Division of Diagnostic Pathology / Surgical Pathology, University of Fukui Hospital, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Kazumi Furuichi (K)

Division of Diagnostic Pathology / Surgical Pathology, University of Fukui Hospital, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Yumi Ito (Y)

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Yoshimasa Imoto (Y)

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Tetsuji Takabayashi (T)

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

Shigeharu Fujieda (S)

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Liquid-based cytology (LBC) with...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Ponction-biopsie à l'aiguille › Cytoponction › Liquid-based cytology (LBC) with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Liquid-based cytology (LBC) with...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Maladies de la glande salivaire › Tumeurs des glandes salivaires › Liquid-based cytology (LBC) with...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Liquid-based cytology (LBC) with...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques histologiques › Techniques de préparation histocytologique › Coloration et marquage › Liquid-based cytology (LBC) with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Liquid-based cytology (LBC) with...