Graphene-based field-effect transistors for biosensing: where is the field heading to?
Bioreceptors
Field-effect transistor
Graphene
Sensing
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
received:
19
04
2023
accepted:
16
05
2023
revised:
13
05
2023
pubmed:
3
6
2023
medline:
3
6
2023
entrez:
3
6
2023
Statut:
ppublish
Résumé
Two-dimensional (2D) materials hold great promise for future applications, notably their use as biosensing channels in the field-effect transistor (FET) configuration. On the road to implementing one of the most widely used 2D materials, graphene, in FETs for biosensing, key issues such as operation conditions, sensitivity, selectivity, reportability, and economic viability have to be considered and addressed correctly. As the detection of bioreceptor-analyte binding events using a graphene-based FET (gFET) biosensor transducer is due to either graphene doping and/or electrostatic gating effects with resulting modulation of the electrical transistor characteristics, the gFET configuration as well as the surface ligands to be used have an important influence on the sensor performance. While the use of back-gating still grabs attention among the sensor community, top-gated and liquid-gated versions have started to dominate this area. The latest efforts on gFET designs for the sensing of nucleic acids, proteins and virus particles in different biofluids are presented herewith, highlighting the strategies presently engaged around gFET design and choosing the right bioreceptor for relevant biomarkers.
Identifiants
pubmed: 37269306
doi: 10.1007/s00216-023-04760-1
pii: 10.1007/s00216-023-04760-1
pmc: PMC10239049
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2137-2150Subventions
Organisme : Agence Nationale de la Recherche
ID : PADISC
Organisme : EuroNanoMed III
ID : GSkin
Informations de copyright
© 2023. Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Desai SB, Madhvapathy SR, Sachid AB, Llinas JP, Wang Q, Ahn GH, et al. MoS
pubmed: 27846499
doi: 10.1126/science.aah4698
Ge X, Xia Z, Guo S. Recent advances on black phosphorus for biomedicine and biosensing. Adv Funct Mater. 2019;29:1900318.
doi: 10.1002/adfm.201900318
Jing X, Illarionov Y, Yalon E, Zhou P, Grasser T, Shi Y, et al. Engineering field effect transistors with 2D semiconducting channels: status and prospects. Adv Funct Mater. 2020;30:1901971.
doi: 10.1002/adfm.201901971
Meng Z, Stolz RM, Mendecki L, Miricica KA. Electrically-transduced chemical sensors based on two-dimensional nanomaterials. Chem Rev. 2019;119:478.
pubmed: 30604969
doi: 10.1021/acs.chemrev.8b00311
Béraud A, Sauvage M, Bazán CM, Tie M, Bencherif M, Bouilly D. Graphene field-effect transistors as bioanalytical sensors: design, operation and performance. Analyst. 2021;146:403.
pubmed: 33215184
doi: 10.1039/D0AN01661F
Mohanty N, Berry V. Graphene-based single-bacterium resolution biodevice and DNA transistor: interfacing graphene derivatives with nanoscale and microscale biocomponents. Nano Lett. 2008;8:4469.
pubmed: 19367973
doi: 10.1021/nl802412n
Palaniappan A, Goh WH, Tey JN, Wijaya IPM, Moochhala SM, Liedberg B, et al. Aligned carbon nanotubes on quartz substrate for liquid gated biosensing. Biosens Bioelectron. 2010;25:1989–93.
pubmed: 20129773
doi: 10.1016/j.bios.2010.01.009
Palaniappan A, Goh WH, Fam DWH, Rajaseger G, Chan CEZ, Hanson BJ, et al. Label-free electronic detection of bio-toxins using aligned carbon nanotubes. Biosens Bioelectron. 2013;43:143–7.
pubmed: 23298625
doi: 10.1016/j.bios.2012.12.019
Lerner MB, Matsunaga F, Han GH, Hong SJ, Xi J, Crook A, et al. Scalable production of highly sensitive nanosensors based on graphene functionalized with a designed G protein-coupled receptor. Nano Lett. 2014;14:27091.
doi: 10.1021/nl5006349
Kwong Hong Tsang D, Lieberthal TJ, Watts C, Dunlop IE, Ramadan S, del Rio Hernandez AE, et al. Chemically functionalised graphene FET biosensor for the label-free sensing of exosomes. Sci Rep. 2019;9:1–10.
doi: 10.1038/s41598-019-50412-9
Hao Z, Pan Y, Shao W, Lin Q, Zhao X. Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva. Biosens Bioelectron. 2019;134:16.
pubmed: 30952012
doi: 10.1016/j.bios.2019.03.053
Wei W, Pallecchi E, Haque S, Borini S, Avramovic V, Centeno A, et al. Mechanically robust 39 GHz cut-off frequency graphene field effect transistors on flexible substrates. Nanoscale. 2016;8(8):14097–103.
pubmed: 27396243
doi: 10.1039/C6NR01521B
Wang B, Zhao C, Wan Z, Yang K-A, Cheng X, Liu W, et al. Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring. Sci Adv. 2022;8:eabk0967.
pubmed: 34985954
pmcid: 8730602
doi: 10.1126/sciadv.abk0967
Zhao C, Man T, Cao Y, Weiss PS, Monbouquette HG, Andrews AM. Flexible and implantable polyimide aptamer-field-effect transistor biosensors. ACS Sens. 2022;7:3644–53.
pubmed: 36399772
pmcid: 9982941
doi: 10.1021/acssensors.2c01909
Park SJ, Kwon OS, Lee SH, Song HS, Park TH, Jang J. Ultrasensitive flexible graphene based field-effect transistor (FET)-type bioelectronic nose. Nano Lett. 2012;12:5082–90.
pubmed: 22962838
doi: 10.1021/nl301714x
Jewel M, Siddiquee T, Islam M. Flexible graphene field effect transistor with graphene oxide dielectric on polyimide substrate. Int Conf Electr Inf Commun Technol (EICT). 2014. https://doi.org/10.1109/EICT.2014.677783418994804 .
doi: 10.1109/EICT.2014.677783418994804
Bai J, Liao L, Zhou H, Cheng R, Liu L, Huang Y, et al. Top-gated chemical vapor deposition grown graphene transistors with current saturation. Nano Lett. 2011;11:2555–9.
pubmed: 21548551
pmcid: 3236244
doi: 10.1021/nl201331x
Guerriero E, Pedrinazzi P, Mansouri A, Habibpour O, Winters M, Rorsman N, et al. High-gain graphene transistors with a thin AlOx top-gate oxide. Sci Rep. 2017;2419:1–7.
Yogeswaran N, Hosseini ES, Dahiya R. Graphene based low voltage field effect transistor coupled with biodegradable piezoelectric material based dynamic pressure sensor. ACS Appl Mater Interfaces. 2020;12:54035.
pubmed: 33205956
doi: 10.1021/acsami.0c13637
Wang Z, Hao Z, Yu S, Huang C, Pan Y, Zhao X. A wearable and deformable graphene-based affinity nanosensor for monitoring of cytokines in biofluids. Nanomaterials. 2020;10:1503.
pubmed: 32751815
pmcid: 7466379
doi: 10.3390/nano10081503
Zhang X, Pu Z, Su X, Li C, Zheng H, Li D. Flexible organic field-effect transistors-based biosensors: progress and perspectives. Anal Bioanal Chem. 2023;415:1607–25.
pubmed: 36719440
pmcid: 9888355
doi: 10.1007/s00216-023-04553-6
Mishyn V, Rodrigues T, Leroux YR, Aspermair P, Happy H, Bintinger J, et al. Controlled covalent functionalization of a graphene-channel of a field effect transistor as an ideal platform for (bio)sensing applications. Nanoscale Horiz. 2021;6:819–29.
pubmed: 34569584
doi: 10.1039/D1NH00355K
Rodrigues T, Mishyn V, Leroux YR, Butruille L, Woitrain E, Barras A, et al. Highly performing graphene-based field effect transistor for the differentiation between mild-moderate-severe myocardial injury. Nano Today. 2022;43:101391.
doi: 10.1016/j.nantod.2022.101391
Mishyn V, Hugo A, Rodrigues T, Aspermair P, Happy H, Marques L, et al. The holy grail of pyrene-based surface ligands on the sensitivity of graphene-based field effect transistors. Sens Diagn. 2021;1:235–44.
doi: 10.1039/D1SD00036E
Hugo A, Rodrigues T, Mader JK, Knoll W, Bouchiat V, Boukherroub R, et al. Matrix metalloproteinase sensing in wound fluids: are graphene-based field effect transistors a viable alternative? Biosensors and Bioelectronics: X. 2023;13:100305.
Rodrigues T, Curti F, Leroux YR, Barras A, Pagneux Q, Happy H, et al. Discovery of a peptide nucleic acid (PNA) aptamer for cardiac troponin I: substituting DNA with neutral PNA maintains picomolar affinity and improves performances for electronic sensing with graphene field-effect transistors (gFET). Nano Today. 2023;50:101840.
doi: 10.1016/j.nantod.2023.101840
Hugo A, Rodrigues T, Mader JK, Knoll W, Bouchiat V, Boukherroub R, et al. Matrix metalloproteinase sensing in wound fluids: are graphene-based field effect transistors a viable alternative. Biosens Bioelectron X. 2023;13:100305.
Gao J, Gao Y, Han Y, Pang J, Wang C, Wang Y, et al. Ultrasensitive label-free MiRNA sensing based on a flexible graphene field-effect transistor without functionalization. ACS Appl Electron Mater. 2020;2:1090–8.
doi: 10.1021/acsaelm.0c00095
Kesler V, Murmann B, Soh HT. Going beyond the Debye length: overcoming charge screening limitations in next- generation bioelectronic sensors. ACS Nano. 2020;14:16194–201.
pubmed: 33226776
pmcid: 7761593
doi: 10.1021/acsnano.0c08622
Gao N, Zhou W, Jiang X, Hong G, Fu T-M, Lieber CM. General strategy for biodetection in high ionic strength solutions using transistor-based nanoelectronic sensors. Nano Lett. 2015;15:2143–8.
pubmed: 25664395
pmcid: 4594804
doi: 10.1021/acs.nanolett.5b00133
Goldsmith BR, Locascio L, Gao Y, Lerner M, Walker A, Lerner J, et al. Digital biosensing by foundry-fabricated graphene sensors. Sci Rep. 2019;9:434.
pubmed: 30670783
pmcid: 6342992
doi: 10.1038/s41598-019-38700-w
Gokturk PA, Sujanani R, Qian J, Wang Y, Katz LE, Freema BD, et al. The Donnan potential revealed. Nat Commun. 2022;13:5880.
doi: 10.1038/s41467-022-33592-3
Song J, Dailey J, Li H, Jang H-J, Zhang P, Tza-Huei Wang J, et al. Extended solution gate OFET-based biosensor for label-free glial fibrillary acidic protein detection with polyethylene glycol-containing bioreceptor layer. Adv Funct Mater. 2017;27:1606506.
pubmed: 29606930
pmcid: 5873605
doi: 10.1002/adfm.201606506
Montaigne D, Marechal X, Modine T, Coisne A, Mouton S, Fayad G, et al. Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study. Lancet. 2018;391(10115):59–69.
pubmed: 29107324
doi: 10.1016/S0140-6736(17)32132-3
Jiang C, Wang HR, Liu N, Luo X, Davis JJ. Antifouling strategies for selective in vitro and in vivo sensing. Chem Rev. 2020;120:3852–89.
pubmed: 32202761
doi: 10.1021/acs.chemrev.9b00739
Russo MJ, Han M, Desroches PE, Manasa CS, Dennaoui J, Quigley AF, et al. Antifouling strategies for electrochemical biosensing: mechanisms and performance toward point of care based diagnostic applications. ACS Sens. 2021;6:1482–507.
pubmed: 33765383
doi: 10.1021/acssensors.1c00390
Hwang MT, Heiranian M, Kim Y, You S, Leem J, Taqieddin A, et al. Ultrasensitive detection of nucleic acids using deformed graphene channel field effect biosensors. Nat Commun. 2020;11:1543.
pubmed: 32210235
pmcid: 7093535
doi: 10.1038/s41467-020-15330-9
Vu C-A, Chen W-Y, et al. Predicting future prospects of aptamers in field-effect transistor biosensors. Molecules. 2020;25:680.
pubmed: 32033448
pmcid: 7036789
doi: 10.3390/molecules25030680
Hasegawa H, Savory N, Abe K, Ikebukuro K. Methods for improving aptamer binding affinity. Molecules. 2016;2:421.
doi: 10.3390/molecules21040421
Hao Z, Pan Y, Huang C, Wang Z, Lin Q, Zhao X, et al. Modulating the linker immobilization density on aptameric graphene field effect transistors using an electric field. ACS Sens. 2020;5:2503–13.
pubmed: 32375472
doi: 10.1021/acssensors.0c00752
Ohno Y, Maehashi K, Matsumoto K. Label-free biosensors based on aptamer-modified graphene field-effect transistors. J Am Chem Soc. 2010;132:18012.
pubmed: 21128665
doi: 10.1021/ja108127r
Kim DJ, Park H-C, Soh IY, Jung J-H, Yoon OJ, Park J-S, et al. Electrical graphene aptasensor for ultra-sensitive detection of anthrax toxin with amplified signal transduction. Small. 2013;9:3352–60.
pubmed: 23589198
doi: 10.1002/smll.201203245
Mazarin de Moraes AC, Kubota LT. Recent trends in field-effect transistors-based immunosensors. Chemosensors. 2016;4:20.
doi: 10.3390/chemosensors4040020
Pagneux Q, Roussel A, Saada H, Cambillau C, Amigues B, Delauzun V, et al. SARS-CoV-2 detection using a nanobodyfunctionalized voltammetric device. Commun Med. 2022;2:56.
pubmed: 35619829
pmcid: 9126950
doi: 10.1038/s43856-022-00113-8
Guo K, Wustoni S, Kokul A, Diaz Galicia E, Moser M, Hama A, et al. Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors. Nat Biomed Eng. 2021;5:666–77.
pubmed: 34031558
doi: 10.1038/s41551-021-00734-9
Gonzalez-Sapienza G, Rossotti MA, Tabares-da Rosa S. Single-domain antibodies as versatile affinity reagents for analytical and diagnostic applications. Front Immunol. 2017;8:977.
pubmed: 28871254
pmcid: 5566570
doi: 10.3389/fimmu.2017.00977
Muyldermans S. Applications of nanobodies. Annu Rev Anim Biosci. 2021;9:401–21.
pubmed: 33233943
doi: 10.1146/annurev-animal-021419-083831
Cheng S, Hotani K, Hideshima S, Kuroiwa S, Nakanishi T, Hashimoto M, et al. Field effect transistor biosensor using antigen binding fragment for detecting tumor marker in human serum. Materials. 2014;7:2490–500.
pubmed: 28788579
pmcid: 5453370
doi: 10.3390/ma7042490
Suderman R, Rice DA, Gibson SD, Strick EJ, Chao D. Development of polyol-responsive antibody mimetics for single-step protein purification. Protein Expr Purif. 2017;134:114–24.
pubmed: 28428153
doi: 10.1016/j.pep.2017.04.008
Pagneux Q, Garnier N, Fabregue M, Sharkaoui S, Mazzoli S, Engelmann I, et al. nanoCLAMP potently neutralizes SARS-CoV-2 and protects K18-hACE2 mice from infection. bioRxiv. 2023. https://doi.org/10.1101/2023.04.03.535401 .
doi: 10.1101/2023.04.03.535401