Age-related Differences in T-cell Subsets and Markers of Subclinical Inflammation in Aging Are Independently Associated With Type 2 Diabetes in the Health and Retirement Study.
CMV seropositivity
age-related immune phenotype
cellules T naïves
cellules T à mémoire
diabetes
diabète
inflammation
memory T cells
naive T cells
phénotype immunitaire lié à l’âge
séropositivité au CMV
Journal
Canadian journal of diabetes
ISSN: 2352-3840
Titre abrégé: Can J Diabetes
Pays: Canada
ID NLM: 101148810
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
28
11
2022
revised:
02
05
2023
accepted:
26
05
2023
pmc-release:
01
10
2024
medline:
23
10
2023
pubmed:
4
6
2023
entrez:
3
6
2023
Statut:
ppublish
Résumé
Age-related changes in adaptive immunity and subclinical inflammation are both important risk factors for diabetes in older adults. We evaluated the independent association between T-cell subsets, subclinical inflammation, and diabetes risk in the Health and Retirement Study (HRS). We measured 11 T-cell subsets, 5 pro-inflammatory markers, and 2 anti-inflammatory markers from the 2016 wave of the HRS (baseline). Diabetes/prediabetes status was estimated at the 2016, 2018, and 2020 waves of HRS, based on levels of blood glucose/glycated hemoglobin in plasma or self-reported status. We used survey generalized logit models to evaluate the cross-sectional associations and Cox proportional hazard models to evaluate longitudinal associations. Among 8,540 participants (56 to 107 years of age), 27.6% had prevalent type 2 diabetes and 31.1% had prediabetes in the 2016 survey. After adjusting for age, sex, race/ethnicity, education, obesity, smoking, comorbidity index, and cytomegalovirus seropositivity, individuals with type 2 diabetes had lower naive T cells and higher memory and terminal effector T cells as compared with normoglycemic individuals. Among 3,230 normoglycemic participants in the 2016 survey, the incidence of diabetes was 1.8% over 4 years of follow-up. The baseline percentage of CD4 This study showed that the baseline percentage of CD4
Identifiants
pubmed: 37269981
pii: S1499-2671(23)00136-3
doi: 10.1016/j.jcjd.2023.05.010
pmc: PMC10592537
mid: NIHMS1906965
pii:
doi:
Substances chimiques
Interleukin-6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
594-602.e6Subventions
Organisme : NIA NIH HHS
ID : R01 AG060110
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG009740
Pays : United States
Informations de copyright
Copyright © 2023 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.
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