Challenges in cybersecurity: Lessons from biological defense systems.

Complex systems Cybersecurity Defense Immunology

Journal

Mathematical biosciences
ISSN: 1879-3134
Titre abrégé: Math Biosci
Pays: United States
ID NLM: 0103146

Informations de publication

Date de publication:
08 2023
Historique:
received: 24 01 2023
revised: 27 04 2023
accepted: 20 05 2023
medline: 28 7 2023
pubmed: 4 6 2023
entrez: 3 6 2023
Statut: ppublish

Résumé

Defending against novel, repeated, or unpredictable attacks, while avoiding attacks on the 'self', are the central problems of both mammalian immune systems and computer systems. Both systems have been studied in great detail, but with little exchange of information across the different disciplines. Here, we present a conceptual framework for structured comparisons across the fields of biological immunity and cybersecurity, by framing the context of defense, considering different (combinations of) defensive strategies, and evaluating defensive performance. Throughout this paper, we pose open questions for further exploration. We hope to spark the interdisciplinary discovery of general principles of optimal defense, which can be understood and applied in biological immunity, cybersecurity, and other defensive realms.

Identifiants

pubmed: 37270102
pii: S0025-5564(23)00065-2
doi: 10.1016/j.mbs.2023.109024
pii:
doi:

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

109024

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest None.

Auteurs

Edward Schrom (E)

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, United States of America.

Ann Kinzig (A)

School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States of America.

Stephanie Forrest (S)

Biodesign Center for Biocomputation, Security and Society, Arizona State University, Tempe, AZ 85287, United States of America; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ 85287, United States of America; Santa Fe Institute, Santa Fe, NM 87501, United States of America.

Andrea L Graham (AL)

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, United States of America; Santa Fe Institute, Santa Fe, NM 87501, United States of America.

Simon A Levin (SA)

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, United States of America. Electronic address: slevin@princeton.edu.

Carl T Bergstrom (CT)

Department of Biology, University of Washington, Seattle, WA 98195, United States of America.

Carlos Castillo-Chavez (C)

School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, United States of America.

James P Collins (JP)

School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States of America.

Rob J de Boer (RJ)

Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands.

Adam Doupé (A)

School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ 85287, United States of America; Center for Cybersecurity and Trusted Foundations, Global Security Initiative, Arizona State University, Tempe, AZ 85287, United States of America.

Roya Ensafi (R)

Department of Electrical Engineering and Computer Science, Computer Science and Engineering Division, University of Michigan, Ann Arbor, MI 48109, United States of America.

Stuart Feldman (S)

Schmidt Futures, New York, NY 10011, United States of America.

Bryan T Grenfell (BT)

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, United States of America; Princeton School of Public and International Affairs, Princeton University, Princeton, NJ 08544, United States of America.

J Alex Halderman (JA)

Department of Electrical Engineering and Computer Science, Computer Science and Engineering Division, University of Michigan, Ann Arbor, MI 48109, United States of America; Center for Computer Security and Society, University of Michigan, Ann Arbor, MI 48109, United States of America.

Silvie Huijben (S)

School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States of America.

Carlo Maley (C)

Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ 85287, United States of America; Biodesign Center for Biocomputation, Security and Society, Arizona State University, Tempe, AZ 85287, United States of America.

Melanie Moses (M)

Department of Computer Science, University of New Mexico, Albuquerque, NM 87131, United States of America; Department of Biology, University of New Mexico, Albuquerque, NM 87131, United States of America; Santa Fe Institute, Santa Fe, NM 87501, United States of America.

Alan S Perelson (AS)

Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, United States of America; Santa Fe Institute, Santa Fe, NM 87501, United States of America.

Charles Perrings (C)

School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States of America.

Joshua Plotkin (J)

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.

Jennifer Rexford (J)

Department of Computer Science, Princeton University, Princeton, NJ 08540, United States of America.

Mohit Tiwari (M)

Department of Electrical and Computer Engineering, University of Texas, Austin, TX 78712, United States of America.

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