Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets.
Cell therapy
Cell–cell contact
Diabetes
Insulin secretion
β-cell subpopulations
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
03 Jun 2023
03 Jun 2023
Historique:
received:
13
03
2023
accepted:
19
05
2023
revised:
27
04
2023
medline:
5
6
2023
pubmed:
4
6
2023
entrez:
3
6
2023
Statut:
epublish
Résumé
Recent studies reported that pancreatic β-cells are heterogeneous in terms of their transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic β-cells have been identified based on the functionality and expression of specific surface markers. Under diabetes condition, β-cell identity is altered leading to different β-cell sub-populations. Furthermore, cell-cell contact between β-cells and other endocrine cells within the islet play an important role in regulating insulin secretion. This highlights the significance of generating a cell product derived from stem cells containing β-cells along with other major islet cells for treating patients with diabetes, instead of transplanting a purified population of β-cells. Another key question is how close in terms of heterogeneity are the islet cells derived from stem cells? In this review, we summarize the heterogeneity in islet cells of the adult pancreas and those generated from stem cells. In addition, we highlight the significance of this heterogeneity in health and disease conditions and how this can be used to design a stem cell-derived product for diabetes cell therapy.
Identifiants
pubmed: 37270452
doi: 10.1007/s00018-023-04815-7
pii: 10.1007/s00018-023-04815-7
pmc: PMC10239390
doi:
Substances chimiques
Insulin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
176Subventions
Organisme : Qatar Biomedical Research Institute, Hamad Bin Khalifa University
ID : Grant No. IGP3
Organisme : Qatar Biomedical Research Institute, Hamad Bin Khalifa University
ID : QBRI-HSCI Project 1
Informations de copyright
© 2023. The Author(s).
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