Modulation of tumour hypoxia by ultrasound-responsive microbubbles to enhance the sono-photodynamic therapy effect on triple-negative breast cancer.

Humans Photochemotherapy / methods Photosensitizing Agents / pharmacology Tumor Hypoxia Cell Line, Tumor Microbubbles Triple Negative Breast Neoplasms / drug therapy Oxygen Porphyrins / pharmacology Chlorophyllides Tumor Microenvironment
Hypoxia Oxygen microbubble Photodynamic Therapy Sono-photodynamic therapy Triple-negative breast cancer Ultrasound

Journal

Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 25 03 2023
revised: 26 05 2023
accepted: 30 05 2023
medline: 3 7 2023
pubmed: 5 6 2023
entrez: 4 6 2023
Statut: ppublish

Résumé

Sono-photodynamic therapy (SPDT) is an oxidative stress-dependant antitumour treatment modality. Due to the hypoxic tumour microenvironment, the antitumour effect of SPDT is limited. In this study, we developed lipid vesicles to transport a photosensitizer (chlorin e6, Ce6) and oxygen into tumours to promote SPDT efficiency on triple-negative breast cancer in vitro and in vivo. The results showed that compared with the same concentration of free Ce6, Lipo-Ce6 produced a higher singlet oxygen level under light irradiation. Cellular Lipo-Ce6 accumulation was 4-fold higher than that of free Ce6. The cytotoxicity on 4T1 cells caused by Lipo-Ce6-SPDT was significantly stronger than that caused by free Ce6-SPDT, and oxygen microbubbles (O

Identifiants

DOI: 10.1016/j.pdpdt.2023.103642 PMID: 37271488
pubmed: 37271488
pii: S1572-1000(23)00369-1
doi: 10.1016/j.pdpdt.2023.103642
pii:
doi:

Substances chimiques

Photosensitizing Agents 0
Oxygen S88TT14065
Porphyrins 0
Chlorophyllides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103642

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Auteurs

Haiping Wang (H)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.

Jinting Shang (J)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China; Huazhong University of Science and Technology; Advanced Technology Institute of Suzhou Chinese Academy of Science,Co.,Ltd.

Fang Yang (F)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.

Song Zhang (S)

Department of Gastroenterology, General Hospital of Central Theater Command, Wuhan 430070, Hubei, China.

Jingsong Cui (J)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.

Xiaoying Hou (X)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.

Yixiang Li (Y)

Medical College, Guangxi University, Nanning 530004, Guangxi, China.

Wei Liu (W)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.

Xiji Shu (X)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.

Yuchen Liu (Y)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China. Electronic address: yuchen.liu@jhun.edu.cn.

Binlian Sun (B)

Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China. Electronic address: binlian17@jhun.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Modulation of tumour hypoxia by...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Modulation of tumour hypoxia by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › Modulation of tumour hypoxia by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › Hypoxie tumorale › Modulation of tumour hypoxia by...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Modulation of tumour hypoxia by...
questionsmedicales.fr › Équipement et fournitures › Microbulles › Modulation of tumour hypoxia by...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeurs du sein triple-négatives › Modulation of tumour hypoxia by...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Modulation of tumour hypoxia by...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Modulation of tumour hypoxia by...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Tétrapyrroles › Chlorophylle › Chlorophyllides › Modulation of tumour hypoxia by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Modulation of tumour hypoxia by...