The Nuances of Hand Transplantation After Sepsis.
Journal
Transplantation
ISSN: 1534-6080
Titre abrégé: Transplantation
Pays: United States
ID NLM: 0132144
Informations de publication
Date de publication:
05 Jun 2023
05 Jun 2023
Historique:
medline:
5
6
2023
pubmed:
5
6
2023
entrez:
5
6
2023
Statut:
aheadofprint
Résumé
Vascularized composite allotransplantation (VCA) of the upper extremity is an established restorative procedure for selected patients with acquired upper limb loss. The majority of upper limb VCAs performed worldwide have been for victims of various forms of trauma. However, in the developed world, amputation following severe sepsis seems to be an increasingly common indication for referral to hand transplant programs. Unlike trauma patients with isolated limb injuries, patients with amputations as a complication of sepsis have survived through a state of global tissue hypoperfusion and multisystem organ failure with severe, enduring effects on the entire body's physiology. This article reviews the unique considerations for VCA candidacy in postsepsis patients with upper limb amputation. These insights may also be relevant to postsepsis patients undergoing other forms of transplantation or to VCA patients requiring additional future solid organ transplants.
Identifiants
pubmed: 37271881
doi: 10.1097/TP.0000000000004665
pii: 00007890-990000000-00430
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no funding or conflicts of interest.
Références
Organ Procurement and Transplantation Network. National data. [Nov 25, 2022]; Available at https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/#.
Wells MW, Rampazzo A, Papay F, et al. Two decades of hand transplantation: a systematic review of outcomes. Ann Plast Surg. 2022;88:335–344.
Kanitakis J, Petruzzo P, Badet L, et al. Chronic rejection in human vascularized composite allotransplantation (hand and face recipients): an update. Transplantation. 2016;100:2053–2061.
Lanzetta M, Petruzzo P, Margreiter R, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation. 2005;79:1210–1214.
Petruzzo P, Sardu C, Lanzetta M, et al. Report (2017) of the International Registry on Hand and Composite Tissue Allotransplantation (IRHCTT). Current Transplantation Reports. 2017;4:294–303.
Oh TK, Song IA. Incidence and associated risk factors for limb amputation among sepsis survivors in South Korea. J Anesth. 2021;35:51–58.
Reitz KM, Kennedy J, Rieser C, et al. The epidemiology of extremity threat and amputation after vasopressor-dependent sepsis. Ann Am Thorac Soc. 2022;19:625–632.
Arshad A, Ayaz A, Rehman S, et al. Progression of acute kidney injury to chronic kidney disease in sepsis survivors: 1-year follow-up study. J Intensive Care Med. 2021;36:1366–1370.
Kumar D, Raynaud M, Chang J, et al. Impact of belatacept conversion on renal function, histology, and gene expression in kidney transplant patients with chronic active antibody-mediated rejection. Transplantation. 2021;105:660–667.
Vincenti F, Rostaing L, Grinyo J, et al. Belatacept and long-term outcomes in kidney transplantation. N Engl J Med. 2016;374:333–343.
Cendales L, Bray R, Gebel H, et al. Tacrolimus to belatacept conversion following hand transplantation: a case report. Am J Transplant. 2015;15:2250–2255.
Grahammer J, Weissenbacher A, Zelger BG, et al. Benefits and limitations of belatacept in 4 hand-transplanted patients. Am J Transplant. 2017;17:3228–3235.
Oliveira TC, Gomes MS, Gomes AC. The crossroads between infection and bone loss. Microorganisms. 2020;8:1765.
Zhao B, Ivashkiv LB. Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors. Arthrit Res Therapy. 2011;13:234.
Puthucheary ZA, Sun Y, Zeng K, et al. Sepsis reduces bone strength before morphologic changes are identifiable. Crit Care Med. 2017;45:e1254–e1261.
Periasamy U, Chilutti M, Kaplan SL, et al. Prevalence of and associations with avascular necrosis after pediatric sepsis: a single-center retrospective study. Pediatr Crit Care Med. 2022;23:e153–e161.
Campbell WN, Joshi M, Sileo D. Osteonecrosis following meningococcemia and disseminated intravascular coagulation in an adult: case report and review. Clin Infect Dis. 1997;24:452–455.
Rinkinen J, Molway D, Carty M, et al. Avascular necrosis of the humeral head following bilateral upper extremity vascular composite allotransplantation: a case report. Case Reports Plast Surg Hand Surg. 2017;4:60–64.
Bueno E, Benjamin MJ, Sisk G, et al. Rehabilitation following hand transplantation. Hand (N Y). 2014;9:9–15.
Kress JP, Hall JB. ICU-acquired weakness and recovery from critical illness. N Engl J Med. 2014;370:1626–1635.
Prescott HC, Angus DC. Enhancing recovery from sepsis: a review. JAMA. 2018;319:62–75.
Singh M, Sisk G, Carty M, et al. Functional outcomes after bilateral hand transplantation: a 3.5-year comprehensive follow-up. Plast Reconstr Surg. 2016;137:185–189.
Kinsley SE, Lenhard NK, Lape EC, et al. Perceived success in upper-extremity vascularized composite allotransplantation: a qualitative study. J Hand Surg Am. 2021;46:711.e1–711.e35.
Kinsley SE, Song S, Petruzzo P, et al. Psychosocial predictors of upper extremity transplantation outcomes: a review of the international registry 1998-2016. Plast Reconstr Surg Glob Open. 2020;8:e3133.
Kinsley SE, Williams EE, Lenhard NK, et al. A provider perspective of psychosocial predictors of upper-extremity vascularized composite allotransplantation success. J Hand Surg Am. 2022;47:387.e1–387.e19.
Winkler D, Rose N, Freytag A, et al. The effects of postacute rehabilitation on mortality, chronic care dependency, health care use, and costs in sepsis survivors. Ann Am Thorac Soc. 2023;20:279–288.
Taylor SP, Murphy S, Rios A, et al. Effect of a multicomponent sepsis transition and recovery program on mortality and readmissions after sepsis: the improving morbidity during post-acute care transitions for sepsis randomized clinical trial. Crit Care Med. 2022;50:469–479.
Taito S, Taito M, Banno M, et al. Rehabilitation for patients with sepsis: a systematic review and meta-analysis. PLoS One. 2018;13:e0201292.
Shen HN, Lu CL, Yang HH. Risk of recurrence after surviving severe sepsis: a matched cohort study. Crit Care Med. 2016;44:1833–1841.