Pluripotent Stem Cell-derived Dopaminergic Neurons for Studying Developmental Neurotoxicity.
Developmental neurotoxicity
Dopaminergic neurons
Environmental health
New approach methodologies
Pluripotent stem cells
Risk assessment
Journal
Stem cell reviews and reports
ISSN: 2629-3277
Titre abrégé: Stem Cell Rev Rep
Pays: United States
ID NLM: 101752767
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
accepted:
08
05
2023
medline:
23
10
2023
pubmed:
5
6
2023
entrez:
5
6
2023
Statut:
ppublish
Résumé
With the vast number of chemicals in commerce, higher throughput strategies are needed to inform risk assessment. The field of toxicology is therefore moving away from traditional in vivo guideline studies towards in vitro new approach methodologies. There has been a great push for such a shift in the field of developmental neurotoxicity, where there is a particular lack of data. A battery of in vitro new approach methodologies has thus been developed to help fill this gap. Included in this battery are assays for numerous processes critical to neurodevelopment, such as proliferation, migration, and synaptogenesis. The current battery of developmental neurotoxicity new approach methodologies still lacks recapitulation of several critical neurodevelopmental processes, including development of neuronal subtypes. With their pluripotency, alongside other advantages, pluripotent stem cells (PSCs) are uniquely suited to address questions of developmental neurotoxicity, as they can recapitulate the different stages of human in vivo neurodevelopment. Among the various neuronal subtypes, development of dopaminergic neurons (DA) is perhaps the best understood and several approaches exist to differentiate PSCs into DA. Herein we review these approaches and propose utilizing PSCs for screening of the impact of environmental chemicals on development of DA. Related techniques and gaps in knowledge are also addressed.
Identifiants
pubmed: 37273171
doi: 10.1007/s12015-023-10555-9
pii: 10.1007/s12015-023-10555-9
pmc: PMC10579108
mid: NIHMS1932950
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2120-2130Subventions
Organisme : Intramural NIH HHS
ID : ZIA ES102745
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA ES103378
Pays : United States
Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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