Protecting RNA quality for spatial transcriptomics while improving immunofluorescent staining quality.

RNA protection RNA quality Visium spatial immunofluorescent staining methanol fixation mouse brain transcriptome spatial transcriptomics

Journal

Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481

Informations de publication

Date de publication:
2023
Historique:
received: 31 03 2023
accepted: 03 05 2023
medline: 5 6 2023
pubmed: 5 6 2023
entrez: 5 6 2023
Statut: epublish

Résumé

In comparison to bulk sequencing or single cell sequencing, spatial transcriptomics preserves the spatial information in tissue slices and can even be mapped to immunofluorescent stainings, allowing translation of gene expression information into their spatial context. This enables to unravel complex interactions of neighboring cells or to link cell morphology to transcriptome data. The 10× Genomics Visium platform offers to combine spatial transcriptomics with immunofluorescent staining of cryo-sectioned tissue slices. We applied this technique to fresh frozen mouse brain slices and developed a protocol that still protects RNA quality while improving buffers for immunofluorescent staining. We investigated the impact of various parameters, including fixation time and buffer composition, on RNA quality and antibody binding. Here, we propose an improved version of the manufacturer protocol, which does not alter RNA quality and facilitates the use of multiple additional antibodies that were not compatible with the manufacturer protocol before. Finally, we discuss the influence of various staining parameters, which contribute to the development of application specific staining protocols.

Identifiants

pubmed: 37274189
doi: 10.3389/fnins.2023.1198154
pmc: PMC10234422
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1198154

Informations de copyright

Copyright © 2023 Hahn, Bens, Kempfer, Reißig, Schmidl and Geis.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Nina Hahn (N)

Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany.
Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.

Martin Bens (M)

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.

Marin Kempfer (M)

Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany.

Christin Reißig (C)

Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany.

Lars Schmidl (L)

Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany.

Christian Geis (C)

Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany.
Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.

Classifications MeSH