Branched chain amino acids in hepatic encephalopathy and sarcopenia in liver cirrhosis: Evidence and uncertainties.
Branched-chain amino acids
Hepatic encephalopathy
Liver cirrhosis
Sarcopenia
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
21 May 2023
21 May 2023
Historique:
received:
28
12
2022
revised:
24
01
2023
accepted:
20
04
2023
medline:
7
6
2023
pubmed:
5
6
2023
entrez:
5
6
2023
Statut:
ppublish
Résumé
Liver cirrhosis is commonly associated with nutritional alterations, reported in 20% of patients with compensated disease and over 60% of patients with decompensated cirrhosis. Nutritional disturbances are associated with a worse prognosis and increased risk of complication. Serum levels of branched-chain amino acids (BCAAs) are decreased in patients with liver cirrhosis. The imbalance of amino acids levels has been suggested to be associated with the development of complications, such as hepatic encephalopathy and sarcopenia, and to affect the clinical presentation and prognosis of these patients. Several studies investigated the efficacy of BCAAs supplementation as a therapeutic option in liver cirrhosis, but uncertainties remain about the real efficacy, the best route of administration, and dosage.
Identifiants
pubmed: 37274800
doi: 10.3748/wjg.v29.i19.2905
pmc: PMC10237095
doi:
Substances chimiques
Amino Acids, Branched-Chain
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2905-2915Informations de copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Références
J Nutr. 2013 Aug;143(8):1263-8
pubmed: 23739310
Cochrane Database Syst Rev. 2017 May 18;5:CD001939
pubmed: 28518283
Hepatology. 2017 Jun;65(6):2045-2058
pubmed: 28195332
Clin Nutr. 2020 Dec;39(12):3533-3562
pubmed: 33213977
Nutrition. 2014 Nov-Dec;30(11-12):1409-14
pubmed: 25280421
Clin Gastroenterol Hepatol. 2005 Jul;3(7):705-13
pubmed: 16206505
Int J Vitam Nutr Res. 2010 Oct;80(4-5):243-8
pubmed: 21462106
Int J Exp Pathol. 2019 Jun;100(3):175-183
pubmed: 31321841
J Hepatol. 2000 May;32(5):748-53
pubmed: 10845661
J Clin Gastroenterol. 2013 Nov-Dec;47(10):861-70
pubmed: 23751844
Hepatology. 1992 Sep;16(3):785-9
pubmed: 1505922
Nutrients. 2020 May 15;12(5):
pubmed: 32429077
Nutrition. 2021 Apr;84:111007
pubmed: 33745507
J Hepatol. 2001 Jul;35(1):37-45
pubmed: 11495040
Nutr Res. 2020 Feb;74:1-9
pubmed: 31891865
Eur J Clin Nutr. 2005 Nov;59 Suppl 2:S31-6
pubmed: 16254578
Int J Exp Pathol. 2018 Dec;99(6):274-281
pubmed: 30637824
J Hepatol. 2022 Feb;76(2):332-342
pubmed: 34571050
Drugs. 2019 Feb;79(Suppl 1):11-16
pubmed: 30706419
J Nutr Sci Vitaminol (Tokyo). 2018;64(5):321-328
pubmed: 30381621
Hepatol Res. 2013 Apr;43(4):365-73
pubmed: 22994500
PLoS One. 2011;6(7):e23037
pubmed: 21829583
Metab Brain Dis. 2013 Jun;28(2):221-5
pubmed: 23275147
Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1292-300
pubmed: 15591158
Surgery. 1976 Jul;80(1):77-91
pubmed: 818729
Nat Commun. 2022 Jul 8;13(1):3964
pubmed: 35803930
Ann Hepatol. 2016 Jan-Feb;15(1):7-16
pubmed: 26626635
Liver Int. 2021 Jun;41(6):1320-1334
pubmed: 33713524
Am J Gastroenterol. 2021 Nov 1;116(11):2241-2249
pubmed: 34074812
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
Hepatol Res. 2017 Mar;47(3):E22-E34
pubmed: 27062043
J Gastroenterol Hepatol. 2019 Jul;34(7):1249-1255
pubmed: 30278111
Nutrients. 2022 Jun 03;14(11):
pubmed: 35684144
Hepatology. 2015 Jun;61(6):2018-29
pubmed: 25613922
Hepatology. 2014 Aug;60(2):715-35
pubmed: 25042402
Nutrients. 2021 Jul 02;13(7):
pubmed: 34371806
Am J Surg. 2002 Apr;183(4):424-9
pubmed: 11975931
Metab Brain Dis. 2009 Mar;24(1):103-17
pubmed: 19104923
Cancer Chemother Pharmacol. 2014 Nov;74(5):899-909
pubmed: 25138286
Eur J Gastroenterol Hepatol. 2017 Dec;29(12):1402-1407
pubmed: 28984678
Nutrients. 2021 Jan 26;13(2):
pubmed: 33530344
Scand J Clin Lab Invest. 2015;75(8):674-80
pubmed: 26243157
Rev Gastroenterol Disord. 2005;5 Suppl 3:26-35
pubmed: 17713457
Eur J Gastroenterol Hepatol. 2017 Dec;29(12):1416-1423
pubmed: 29016470
Hepatology. 2017 Aug;66(2):564-574
pubmed: 28422306
N Engl J Med. 2010 Mar 25;362(12):1071-81
pubmed: 20335583
J Gastroenterol. 2018 Mar;53(3):427-437
pubmed: 28741271
Metabol Open. 2021 Jun 29;11:100105
pubmed: 34337376
Hepatology. 2019 Jan;69(1):107-120
pubmed: 29665135
J Hepatol. 2022 Sep;77(3):807-824
pubmed: 35724930
J Clin Med. 2020 Oct 10;9(10):
pubmed: 33050430
Hepatology. 1984 Mar-Apr;4(2):279-87
pubmed: 6706302
Lancet. 1971 Jul 10;2(7715):75-80
pubmed: 4103986
Clin Nutr ESPEN. 2021 Feb;41:13-22
pubmed: 33487256
J Hepatol. 2016 Dec;65(6):1232-1244
pubmed: 27515775
Genes Nutr. 2014 Nov;9(6):436
pubmed: 25367142
Clin Nutr. 2021 Apr;40(4):1879-1892
pubmed: 33268143
Hepatol Res. 2012 Jul;42(7):658-67
pubmed: 22380706
J Clin Exp Hepatol. 2019 Jan-Feb;9(1):125-130
pubmed: 30765945
J Clin Exp Hepatol. 2018 Dec;8(4):448-451
pubmed: 30568347
J Clin Med Res. 2018 May;10(5):437-444
pubmed: 29581807
Nutrition. 2015 Jan;31(1):14-20
pubmed: 25220875
Medicine (Baltimore). 2017 Jun;96(24):e6580
pubmed: 28614215
Am J Gastroenterol. 2011 Jun;106(6):1081-8
pubmed: 21326220
Int J Mol Sci. 2021 Jan 31;22(3):
pubmed: 33572604
J Gastroenterol. 2021 Oct;56(10):928-937
pubmed: 34533633
Gastroenterology. 1982 Sep;83(3):664-71
pubmed: 7095369