Population genetics of group B
Streptococcus agalactiae
antimicrobial resistance
clonal complexes
group B Streptococcus
maternal carriage
maternal immunization
serotypes
vaccine
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
03
2023
accepted:
25
04
2023
medline:
5
6
2023
pubmed:
5
6
2023
entrez:
5
6
2023
Statut:
epublish
Résumé
Maternal immunization against Group B In this study we characterized the population structure of GBS isolates from maternal carriage ( The isolates clustered into nine clonal complexes (CCs) but the majority (95%) belonged to five lineages: CC1 (26%), CC19 (26%), CC23 (20%), CC17 (13%) and CC8/10 (10%). Nine serotypes were identified, the most common were serotypes III (26%), V (21%), II (19%) and Ia (19%). Other serotypes (Ib, IV, VI, VII, IX) represented less than 10% of all isolates each. Intra-lineage serotype diversity was observed in all major CCs but was highest in CC1, which revealed nine serotypes. Nearly all isolates (99%) carried at least one of the four alpha family protein genes ( Our study showed high prevalence of GBS vaccine targets among isolates from pregnant women in London. However, the observed serotype diversity in CC1 and high prevalence of MLS
Identifiants
pubmed: 37275158
doi: 10.3389/fmicb.2023.1185753
pmc: PMC10233156
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1185753Informations de copyright
Copyright © 2023 Jamrozy, Gopal Rao, Feltwell, Lamagni, Khanna, Efstratiou, Parkhill and Bentley.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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