The Protective Potential Role of ACE2 against COVID-19.
Journal
Advances in virology
ISSN: 1687-8639
Titre abrégé: Adv Virol
Pays: United States
ID NLM: 101508613
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
11
2022
revised:
22
11
2022
accepted:
16
05
2023
medline:
5
6
2023
pubmed:
5
6
2023
entrez:
5
6
2023
Statut:
epublish
Résumé
Due to the coronavirus disease 2019 (COVID-19), researchers all over the world have tried to find an appropriate therapeutic approach for the disease. The angiotensin-converting enzyme 2 (ACE2) has been shown as a necessary receptor to cell fusion, which is involved in infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is commonly crucial for all organs and systems. When ACE2 is downregulated via the SARS-CoV-2 spike protein, it results in the angiotensin II (Ang II)/angiotensin type 1 receptor axis overactivation. Ang II has harmful effects, which can be evidenced by dysfunctions in many organs experienced by COVID-19 patients. ACE2 is the SARS-CoV-2 receptor and has an extensive distribution; thus, some COVID-19 cases experience several symptoms and complications. We suggest strategy for the potential protective effect of ACE2 to the viral infection. The current review will provide data to develop new approaches for preventing and controlling the COVID-19 outbreak.
Identifiants
pubmed: 37275947
doi: 10.1155/2023/8451931
pmc: PMC10238138
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
8451931Informations de copyright
Copyright © 2023 Fereshteh Golab et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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