Asymmetric Synthesis of Remotely Chiral Naphthols and Naphthylamines via Naphthoquinone Methides.

Quinone methides are well-established intermediates in asymmetric synthesis. In contrast, their extended analogues with the carbonyl and methide units distributed across two different rings have not been exploited in asymmetric synthesis. Herein, we achieved the first asymmetric process involving such intermediates. Specifically, the use of suitable chiral phosphoric acids enabled