Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling by PKCδ during Plasticity.
CREB
FRET
PKC
plasticity
sensor
synapse
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
26 07 2023
26 07 2023
Historique:
received:
27
01
2022
revised:
18
05
2023
accepted:
27
05
2023
pmc-release:
26
01
2024
medline:
28
7
2023
pubmed:
6
6
2023
entrez:
5
6
2023
Statut:
ppublish
Résumé
The activity-dependent plasticity of synapses is believed to be the cellular basis of learning. These synaptic changes are mediated through the coordination of local biochemical reactions in synapses and changes in gene transcription in the nucleus to modulate neuronal circuits and behavior. The protein kinase C (PKC) family of isozymes has long been established as critical for synaptic plasticity. However, because of a lack of suitable isozyme-specific tools, the role of the novel subfamily of PKC isozymes is largely unknown. Here, through the development of fluorescence lifetime imaging-fluorescence resonance energy transfer activity sensors, we investigate novel PKC isozymes in synaptic plasticity in CA1 pyramidal neurons of mice of either sex. We find that PKCδ is activated downstream of TrkB and DAG production, and that the spatiotemporal nature of its activation depends on the plasticity stimulation. In response to single-spine plasticity, PKCδ is activated primarily in the stimulated spine and is required for local expression of plasticity. However, in response to multispine stimulation, a long-lasting and spreading activation of PKCδ scales with the number of spines stimulated and, by regulating cAMP response-element binding protein activity, couples spine plasticity to transcription in the nucleus. Thus, PKCδ plays a dual functional role in facilitating synaptic plasticity.
Identifiants
pubmed: 37277178
pii: JNEUROSCI.0208-22.2023
doi: 10.1523/JNEUROSCI.0208-22.2023
pmc: PMC10376934
doi:
Substances chimiques
Isoenzymes
0
Protein Kinase C
EC 2.7.11.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5432-5447Subventions
Organisme : NIMH NIH HHS
ID : F32 MH101954
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH080047
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS116804
Pays : United States
Informations de copyright
Copyright © 2023 the authors.
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