Ultra-high field magnetic resonance imaging of the quadriceps tendon enthesis in healthy subjects.
Enthesis
Quadriceps tendon
T2* mapping
UHF MRI
Journal
Surgical and radiologic anatomy : SRA
ISSN: 1279-8517
Titre abrégé: Surg Radiol Anat
Pays: Germany
ID NLM: 8608029
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
10
02
2023
accepted:
24
05
2023
medline:
24
7
2023
pubmed:
6
6
2023
entrez:
5
6
2023
Statut:
ppublish
Résumé
Although enthesitis is a hallmark of several rheumatologic conditions, current imaging methods are still unable to characterize entheses changes because of the corresponding short transverse relaxation times (T2). A growing number of MR studies have used Ultra-High Field (UHF) MRI in order to assess low-T2 tissues e.g., tendon but never in humans. The purpose of the present study was to assess in vivo the enthesis of the quadriceps tendon in healthy subjects using UHF MRI. Eleven healthy subjects volunteered in an osteoarthritis imaging study. The inclusion criteria were: no knee trauma, Lequesne index = 0, less than 3 h of sport activities per week, and Kellgren and Lawrence grade = 0. 3D MR images were acquired at 7 T using GRE sequences and a T2* mapping. Regions of interest i.e., trabecular bone, subchondral bone, enthesis, and tendon body were identified, and T2* values were quantified and compared. Quadriceps tendon enthesis was visible as a hyper-intense signal. The largest and the lowest T2* values were quantified in the subchondral bone region and the tendon body respectively. T2* value within subchondral bone was significantly higher than T2* value within the enthesis. T2* in subchondral bone region was significantly higher than the whole tendon body T2*. A T2* gradient was observed along the axis from the enthesis toward the tendon body. It illustrates different water biophysical properties. These results provide normative values which could be used in the field of inflammatory rheumatologic diseases and mechanical disorders affecting the tendon.
Identifiants
pubmed: 37277665
doi: 10.1007/s00276-023-03175-y
pii: 10.1007/s00276-023-03175-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1049-1054Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.
Références
Benjamin M, Kumai T, Milz S, Boszczyk BM, Boszczyk AA, Ralphs JR (2002) The skeletal attachment of tendons—tendon ‘entheses.’ Comp Biochem Physiol A: Mol Integr Physiol 133:931–945. https://doi.org/10.1016/s1095-6433(02)00138-1
doi: 10.1016/s1095-6433(02)00138-1
pubmed: 12485684
Rossetti L, Kuntz LA, Kunold E et al (2017) The microstructure and micromechanics of the tendon–bone insertion. Nature Mater 16:664–670. https://doi.org/10.1038/nmat4863
doi: 10.1038/nmat4863
Milz S, Benjamin M, Putz R (2005) Molecular parameters indicating adaptation to mechanical stress in fibrous connective tissue. Adv Anat Embryol Cell Biol 178:1–71
pubmed: 16080262
Salah MM, Yong YR, Poh WT, Chong LR (2019) Multiple spontaneous tendon ruptures from enthesis failure in primary hyperparathyroidism: a case report and review of imaging findings. Skeletal Radiol 48:1279–1287. https://doi.org/10.1007/s00256-018-3092-4
doi: 10.1007/s00256-018-3092-4
pubmed: 30353279
Wu W, Wang C, Ruan J, Wang H, Huang Y, Zheng W, Chen F (2019) Simultaneous spontaneous bilateral quadriceps tendon rupture with secondary hyperparathyroidism in a patient receiving hemodialysis: a case report. Medicine 98:e14809. https://doi.org/10.1097/MD.0000000000014809
doi: 10.1097/MD.0000000000014809
pubmed: 30855501
pmcid: 6417630
Resnick D, Niwayama G (1976) Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 119:559–568. https://doi.org/10.1148/119.3.559
doi: 10.1148/119.3.559
pubmed: 935390
Vaishya R, Vijay V, Nwagbara IC, Agarwal AK (2017) Diffuse idiopathic skeletal hyperostosis (DISH)–a common but less known cause of back pain. J Clin Orthop Trauma 8:191–196. https://doi.org/10.1016/j.jcot.2016.11.006
doi: 10.1016/j.jcot.2016.11.006
pubmed: 28721001
Herrou J, Picaud AS, Lassalle L et al (2022) Prevalence of enthesopathies in adults with X-linked hypophosphatemia: analysis of risk factors. J Clin Endocrinol Metab 107:e224–e235. https://doi.org/10.1210/clinem/dgab580
doi: 10.1210/clinem/dgab580
pubmed: 34406383
Braun J, Bollow M, Eggens U, König H, Distler A, Sieper J (1994) Use of dynamic magnetic resonance imaging with fast imaging in the detection of early and advanced sacroiliitis in spondylarthropathy patients. Arthritis Rheum 37:1039–1045. https://doi.org/10.1002/art.1780370709
doi: 10.1002/art.1780370709
pubmed: 8024613
Rudwaleit M, Jurik AG, Hermann K-GA et al (2009) Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group. Ann Rheum Dis 68:1520–1527. https://doi.org/10.1136/ard.2009.110767
doi: 10.1136/ard.2009.110767
pubmed: 19454404
McGonagle D, Conaghan PG, O’Connor P et al (1999) The relationship between synovitis and bone changes in early untreated rheumatoid arthritis: a controlled magnetic resonance imaging study. Arthritis Rheum 42:1706–1711. https://doi.org/10.1002/1529-0131(199908)42:8%3c1706::AID-ANR20%3e3.0.CO;2-Z
doi: 10.1002/1529-0131(199908)42:8<1706::AID-ANR20>3.0.CO;2-Z
pubmed: 10446871
Chen B, Zhao Y, Cheng X et al (2018) Three-dimensional ultrashort echo time cones (3D UTE-Cones) magnetic resonance imaging of entheses and tendons. Magn Reson Imaging 49:4–9. https://doi.org/10.1016/j.mri.2017.12.034
doi: 10.1016/j.mri.2017.12.034
pubmed: 29309823
Juras V, Zbyn S, Pressl C, Valkovic L, Szomolanyi P, Frollo I, Trattnig S (2012) Regional variations of T
doi: 10.1002/mrm.24136
pubmed: 22851221
Trudel G, Melkus G, Cron GO et al (2017) Imaging of the rabbit supraspinatus enthesis at 7 Tesla: a 4-week time course after repair surgery and effect of channeling: enthesis reformation at 7T: experimental study. J Magn Reson Imaging 46:461–467. https://doi.org/10.1002/jmri.25589
doi: 10.1002/jmri.25589
pubmed: 28152242
Jenkinson M, Beckmann CF, Behrens TEJ, Woolrich MW, Smith SM (2012) FSL. Neuroimage 62(2):782–790. https://doi.org/10.1016/j.neuroimage.2011.09.015
doi: 10.1016/j.neuroimage.2011.09.015
pubmed: 21979382
Ogier A, Sdika M, Foure A, Le Troter A, Bendahan D (2017) Individual muscle segmentation in MR images: A 3D propagation through 2D non-linear registration approaches. Conf Proc IEEE Eng Med Biol Soc 2017:317–320. https://doi.org/10.1109/EMBC.2017.8036826
doi: 10.1109/EMBC.2017.8036826
Nöbauer-Huhmann I-M, Pretterklieber M, Erhart J et al (2012) Anatomy and variants of the triangular fibrocartilage complex and its MR appearance at 3 and 7T. Semin Musculoskelet Radiol 16:93–103. https://doi.org/10.1055/s-0032-1311761
doi: 10.1055/s-0032-1311761
pubmed: 22648425
Toumi H, Larguech G, Filaire E, Pinti A, Lespessailles E (2012) Regional variations in human patellar trabecular architecture and the structure of the quadriceps enthesis: a cadaveric study: Patellar trabecular architecture and the structure of the quadriceps enthesis. J Anat 220:632–637. https://doi.org/10.1111/j.1469-7580.2012.01500.x
doi: 10.1111/j.1469-7580.2012.01500.x
pubmed: 22458636
pmcid: 3390516
Juras V, Mlynarik V, Szomolanyi P, Valkovič L, Trattnig S (2019) Magnetic resonance imaging of the musculoskeletal system at 7T: morphological Imaging and Beyond. Top Magn Reson Imaging 28:125–135. https://doi.org/10.1097/RMR.0000000000000205
doi: 10.1097/RMR.0000000000000205
pubmed: 30951006
pmcid: 6565434
Chang G, Boone S, Martel D et al (2017) MRI assessment of bone structure and microarchitecture. J Magn Reson Imaging 46:323–337. https://doi.org/10.1002/jmri.25647
doi: 10.1002/jmri.25647
pubmed: 28165650
pmcid: 5690546
Benjamin M, Milz S, Bydder GM (2008) Magnetic resonance imaging of entheses. Part 1. Clin Radiol 63:691–703. https://doi.org/10.1016/j.crad.2007.12.011
doi: 10.1016/j.crad.2007.12.011
pubmed: 18455562
Benjamin M, Toumi H, Suzuki D, Redman S, Emery P, McGonagle D (2007) Microdamage and altered vascularity at the enthesis–bone interface provides an anatomic explanation for bone involvement in the HLA–B27–associated spondylarthritides and allied disorders. Arthritis Rheum 56:224–233. https://doi.org/10.1002/art.22290
doi: 10.1002/art.22290
pubmed: 17195226
Chen B, Cheng X, Dorthe EW et al (2019) Evaluation of normal cadaveric Achilles tendon and enthesis with ultrashort echo time (UTE) magnetic resonance imaging and indentation testing. NMR Biomed 32:e4034. https://doi.org/10.1002/nbm.4034
doi: 10.1002/nbm.4034
pubmed: 30457179
Juras V, Apprich S, Szomolanyi P, Bieri O, Deligianni X, Trattnig S (2013) Bi-exponential T2 analysis of healthy and diseased Achilles tendons: an in vivo preliminary magnetic resonance study and correlation with clinical score. Eur Radiol 23:2814–2822. https://doi.org/10.1007/s00330-013-2897-8
doi: 10.1007/s00330-013-2897-8
pubmed: 23760303
pmcid: 3769589
Diaz E, Chung CB, Bae WC et al (2012) Ultrashort echo time spectroscopic imaging (UTESI): an efficient method for quantifying bound and free water. NMR Biomed 25:161–168. https://doi.org/10.1002/nbm.1728
doi: 10.1002/nbm.1728
pubmed: 21766381
Devaprakash D, Obst SJ, Lloyd DG et al (2020) The free achilles tendon is shorter, stiffer, has larger cross-sectional area and longer T2* relaxation time in trained middle-distance runners compared to healthy controls. Front Physiol 11:965. https://doi.org/10.3389/fphys.2020.00965
doi: 10.3389/fphys.2020.00965
pubmed: 32973544
pmcid: 7482361
Du J, Pak BC, Znamirowski R et al (2009) Magic angle effect in magnetic resonance imaging of the Achilles tendon and enthesis. Magn Reson Imaging 27:557–564. https://doi.org/10.1016/j.mri.2008.09.003
doi: 10.1016/j.mri.2008.09.003
pubmed: 19022600
Hansen M, Kjaer M (2016) Sex hormones and tendon. Adv Exp Med Biol 920:139–149. https://doi.org/10.1007/978-3-319-33943-6_13
doi: 10.1007/978-3-319-33943-6_13
pubmed: 27535256