Prognostic role of E2F1 gene expression in human cancer: a meta-analysis.


Journal

BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800

Informations de publication

Date de publication:
05 Jun 2023
Historique:
received: 25 10 2022
accepted: 20 04 2023
medline: 7 6 2023
pubmed: 6 6 2023
entrez: 5 6 2023
Statut: epublish

Résumé

E2F1 has been confirmed to be highly expressed in a variety of cancers. To better understand the prognostic value of E2F1 in cancer patients, this study was conducted to comprehensively evaluate the prognostic value of E2F1 in cancer according to published data. PubMed, Web of Science and CNKI database were searched until May 31 A total of 17 articles were included in this study involved in 4481 cancer patients. The pooled results showed that higher E2F1 expression was significantly correlated with unfavorable overall survival (HR = 1.10, I E2F1 could be served as a prognostic biomarker in cancer patients and higher levels of in cancer patients could predict shorter overall survival and disease-free survival.

Identifiants

pubmed: 37277745
doi: 10.1186/s12885-023-10865-8
pii: 10.1186/s12885-023-10865-8
pmc: PMC10243032
doi:

Substances chimiques

E2F1 protein, human 0
E2F1 Transcription Factor 0

Types de publication

Meta-Analysis Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

509

Informations de copyright

© 2023. The Author(s).

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Auteurs

Jingjing Li (J)

Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Wen Bi (W)

Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Fang Lu (F)

School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Department of Pharmacy, Nanjing First Hospital, China Pharmaceutical University, Nanjing, China.

Bei Pan (B)

Medical College, Southeast University, Nanjing, 210006, China.

Mengqiu Xiong (M)

Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Lubanga Nasifu (L)

Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Department of Biology, Muni University, Arua, Uganda.

Zhenlin Nie (Z)

Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. Zhenlinnie@126.com.
Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 210006, China. Zhenlinnie@126.com.

Bangshun He (B)

Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. bhe@njmu.edu.cn.
Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 210006, China. bhe@njmu.edu.cn.

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Classifications MeSH