Ivermectin drug induced liver injury.

Female Humans Ivermectin / adverse effects COVID-19 / pathology South Africa Liver / pathology Chemical and Drug Induced Liver Injury / etiology

Journal

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
ISSN: 2078-5135
Titre abrégé: S Afr Med J
Pays: South Africa
ID NLM: 0404520

Informations de publication

Date de publication:
05 06 2023
Historique:
received: 20 12 2022
accepted: 13 01 2023
medline: 7 6 2023
pubmed: 6 6 2023
entrez: 6 6 2023
Statut: epublish

Résumé

Ivermectin remains a popular, albeit unproven, therapy used in both the prevention and treatment of COVID-19. We discuss a patient who developed jaundice and a liver injury 3 weeks after initiating ivermectin for COVID prevention.  Liver histology demonstrated a pattern of injury that was both portal and lobular, with a bile ductulitis as well with marked cholesasis. She was managed with low dose corticosteroids, later tapered and withdrawn. She remains well a year after presenting.

Identifiants

DOI: 10.7196/SAMJ.2023.v113i6.624 PMID: 37278267
pubmed: 37278267
doi: 10.7196/SAMJ.2023.v113i6.624
doi:

Substances chimiques

Ivermectin 70288-86-7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

24-25

Auteurs

Mark Sonderup (M)

Division of Hepatology and Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital. msonderup@samedical.co.za.

Washington Mudini (W)

Department of Anatomical Pathology and the National Health Laboratory System, D7, University of Cape Town and Groote Schuur Hospital. drmudini@gmail.com.

Wendy Spearman (W)

Division of Hepatology and Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital. wendy.spearman@uct.ac.za.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ivermectin drug induced liver injury.
questionsmedicales.fr › Composés chimiques organiques › Lactones › Ivermectine › Ivermectin drug induced liver injury.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Ivermectin drug induced liver injury.
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique australe › République d'Afrique du Sud › Ivermectin drug induced liver injury.
questionsmedicales.fr › Système digestif › Foie › Ivermectin drug induced liver injury.
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Ivermectin drug induced liver injury.