An MRI Deep Learning Model Predicts Outcome in Rectal Cancer.

Male Humans Middle Aged Retrospective Studies Deep Learning Rectal Neoplasms / diagnostic imaging Magnetic Resonance Imaging Risk Factors

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
06 2023
Historique:
medline: 8 6 2023
pubmed: 6 6 2023
entrez: 6 6 2023
Statut: ppublish

Résumé

Background Deep learning (DL) models can potentially improve prognostication of rectal cancer but have not been systematically assessed. Purpose To develop and validate an MRI DL model for predicting survival in patients with rectal cancer based on segmented tumor volumes from pretreatment T2-weighted MRI scans. Materials and Methods DL models were trained and validated on retrospectively collected MRI scans of patients with rectal cancer diagnosed between August 2003 and April 2021 at two centers. Patients were excluded from the study if there were concurrent malignant neoplasms, prior anticancer treatment, incomplete course of neoadjuvant therapy, or no radical surgery performed. The Harrell C-index was used to determine the best model, which was applied to internal and external test sets. Patients were stratified into high- and low-risk groups based on a fixed cutoff calculated in the training set. A multimodal model was also assessed, which used DL model-computed risk score and pretreatment carcinoembryonic antigen level as input. Results The training set included 507 patients (median age, 56 years [IQR, 46-64 years]; 355 men). In the validation set (

Identifiants

DOI: 10.1148/radiol.222223 PMID: 37278629
pubmed: 37278629
doi: 10.1148/radiol.222223
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e222223

Commentaires et corrections

Type : CommentIn

Auteurs

Xiaofeng Jiang (X)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0002-3716-8232

Hengyu Zhao (H)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).

Oliver Lester Saldanha (OL)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).

Sven Nebelung (S)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0002-5267-9962

Christiane Kuhl (C)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0001-8696-2363

Iakovos Amygdalos (I)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0002-5138-4214

Sven Arke Lang (SA)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0003-4455-5676

Xiaojian Wu (X)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0001-5610-2530

Xiaochun Meng (X)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0002-1302-0380

Daniel Truhn (D)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0002-9605-0728

Jakob Nikolas Kather (JN)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).
ORCID: 0000-0002-3730-5348

Jia Ke (J)

From the Departments of Colorectal Surgery and General Surgey (X.J., H.Z., X.W., J.K.) and Radiology (X.M.), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, China (X.J., H.Z., X.W., X.M., J.K.); Department of Medicine III (X.J., O.L.S., J.N.K.), Department of Diagnostic and Interventional Radiology (X.J., S.N., C.K., D.T.), and Department of Surgery and Transplantation (I.A., S.A.L.), University Hospital RWTH Aachen, Aachen, Germany; and Else Kröner Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany (X.J., O.L.S., J.N.K.).

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