A novel marker for predicting type 1 retinopathy of prematurity: C-reactive protein/albumin ratio.
Albumin
C-reactive protein
CRP-to-albumin ratio
Lymphocyte
Neutrophil
Retinopathy of prematurity
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
27
12
2022
accepted:
06
05
2023
medline:
4
8
2023
pubmed:
6
6
2023
entrez:
6
6
2023
Statut:
ppublish
Résumé
We aimed to investigate whether the C-reactive protein (CRP) to albumin ratio (CAR) an inflammatory predictor can be used as a marker for the development of ROP. Gestational age, birth weight, gender, neonatal, and maternal risk factors were recorded. The patients were divided into two groups: those who did not develop ROP (ROP -) and those who developed ROP (ROP +). The ROP + group was further separated into two groups: those who required treatment (ROP + T) and those who were not treated (ROP + NT). The following parameters were noted in the first postnatal week and at the end of the first postnatal month: CRP, albumin, CAR, white blood cell (WBC), neutrophil, lymphocyte, neutrophil-to-lymphocyte ratio (NLR), distribution red cell width (RDW), platelet (Plt), and RDW/platelet ratio. We evaluated 131 premature infants who met the inclusion criteria. There was no difference between the main groups in hemogram parameters and CAR at the postnatal first week. WBC count (p = 0.011), neutrophil count (p = 0.002), and NLR were high (p = 0.004) in the ROP + group at the end of the postnatal 1st month. The CAR level at the end of the first month was higher in the ROP + group (p = 0.027). CAR was similar between the ROP + T and ROP + NT groups (p = 0.112) in the postnatal first week but higher in the treatment-required group at the end of the first month (p < 0.01). High CAR and high NLR at the end of the postnatal first month can be used to predict the development of severe ROP.
Identifiants
pubmed: 37278868
doi: 10.1007/s10792-023-02740-z
pii: 10.1007/s10792-023-02740-z
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3345-3353Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Fielder A, Blencowe H, O’Connor A, Gilbert C (2015) Impact of retinopathy of prematurity on ocular structures and visual functions. Arch Dis Child Fetal Neonatal Ed 100(2):179–184. https://doi.org/10.1136/archdischild-2014-306207
doi: 10.1136/archdischild-2014-306207
Küçükevcilioğlu M, Mutlu FM, Sarıcı SÜ (2015) Ocular morbidities of premature children with mild or no retinopathy of prematurity. Turk J Pediatr 57(2):129–135
pubmed: 26690592
Zhu X, Zhao R, Wang Y, Ouyang L et al (2017) Refractive state and optical compositions of preterm children with and without retinopathy of prematurity in the first 6 years of life. Medicine (Baltimore) 96(45):8565. https://doi.org/10.1097/MD.0000000000008565
doi: 10.1097/MD.0000000000008565
Kumar P, Sankar MJ, Deorari A, Azad R et al (2011) Risk factors for severe retinopathy of prematurity in preterm low birth weight neonates. Indian J Pediatr 78(7):812–816. https://doi.org/10.1007/s12098-011-0363-7
doi: 10.1007/s12098-011-0363-7
pubmed: 21340729
Baş AY, Demirel N, Koc E, Ulubas Isik D et al, TR-ROP Study Group (2018) Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units. Br J Ophthalmol 102(12):1711–1716. https://doi.org/10.1136/bjophthalmol-2017-311789
Chang JW (2019) Risk factor analysis for the development and progression of retinopathy of prematurity. PLoS One 14(7):0219934. https://doi.org/10.1371/journal.pone.0219934
Rao AK, Purkayastha J, Hazarika M, Chaitra R, Adith KM (2013) Analysis of prenatal and postnatal risk factors of retinopathy of prematurity in a tertiary care hospital in South India. Indian J Ophthalmol 61(11):640–644. https://doi.org/10.4103/0301-4738.119347
doi: 10.4103/0301-4738.119347
pubmed: 24145565
pmcid: 3959079
Rivera JC, Holm M, Austeng D, Morken TS et al (2017) Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies. J Neuroinflammation 14(1):165. https://doi.org/10.1186/s12974-017-0943-1
doi: 10.1186/s12974-017-0943-1
pubmed: 28830469
pmcid: 5567917
Lee J, Dammann O (2012) Perinatal infection, inflammation, and retinopathy of prematurity. Semin Fetal Neonatal Med 17(1):26–29. https://doi.org/10.1016/j.siny.2011.08.007
doi: 10.1016/j.siny.2011.08.007
pubmed: 21903492
Beaudry-Richard A, Nadeau-Vallée M, Prairie É, Maurice N et al (2018) Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny. Sci Rep 8(1):11875. https://doi.org/10.1038/s41598-018-30087-4
doi: 10.1038/s41598-018-30087-4
pubmed: 30089839
pmcid: 6082873
Lynch AM, Berning AA, Thevarajah TS, Wagner BD et al (2018) The role of the maternal and fetal inflammatory response in retinopathy of prematurity. Am J Reprod Immunol 83(1):12986. https://doi.org/10.1111/aji.12986
doi: 10.1111/aji.12986
Sullivan JL (1986) Retinopathy of prematurity and iron: a modification of the oxygen hypothesis. Pediatrics 78(6):1171–1172
doi: 10.1542/peds.78.6.1171
pubmed: 3786050
Szade A, Grochot-Przeczek A, Florczyk U, Jozkowicz A, Dulak J (2015) Cellular and molecular mechanisms of inflammation-induced angiogenesis. IUBMB Life 67(3):145–159. https://doi.org/10.1002/iub.1358
Yu H, Yuan L, Zou Y, Peng L et al (2014) Serum concentrations of cytokines in infants with retinopathy of prematurity. APMIS 122(9):818–823. https://doi.org/10.1111/apm.12223
doi: 10.1111/apm.12223
pubmed: 24479831
Holm M, Morken TS, Fichorova RN, VanderVeen DK, et al. for the ELGAN Study Neonatology and Ophthalmology Committees (2017) Systemic inflammation-associated proteins and retinopathy of prematurity in infants born before the 28th week of gestation. IOVS 58(14);6419–6428. https://doi.org/10.1167/iovs.17-21931
Parrozzani R, Nacci EB , Bini S, Marchione G et al (2021) Severe retinopathy of prematurity is associated with early post-natal low platelet count. Sci Reports 11(1):891. https://doi.org/10.1038/s41598-020-79535-0
Morris I, McCallion N, El-Khuffash A, Molloy EJ (2008) Serum albumin and mortality in very low birth weight infants. Arch Dis Child Fetal Neonatal Ed 93(4):310–312. https://doi.org/10.1136/adc.2007.131375
doi: 10.1136/adc.2007.131375
Lee M, Youn S, Lim BK, Kim JS (2005) Serum albumin concentrations and clinical disorders by gestational ages in Preterm Babies. Korean J Pediatr 48(2):148–153
Bai M , Wu Y, Ji Z , Wang S et al. (2019) Prognostic value of C-reactive protein/albumin ratio in neurocritically ill patients. Minerva Anestesiol 85(12):1299–1307. https://doi.org/10.23736/S0375-9393.19.13625-5
Ni XF, Wu J, Ji M, Shao YJ et al (2018) Effect of C-reactive protein/albumin ratio on prognosis in advanced non-small-cell lung cancer. Asia Pac J Clin Oncol 14(6):402–409. https://doi.org/10.1111/ajco.13055
doi: 10.1111/ajco.13055
pubmed: 30178541
Güneş H, Yurttutan S , Çobanuşağı M, Doğaner A (2021) CRP/albumin ratio: a promising marker of gram-negative bacteremia in late-onset neonatal sepsis. Turk Arch Pediatr 56(1):32–36. https://doi.org/10.14744/TurkPediatriArs.2020.99076
doi: 10.14744/TurkPediatriArs.2020.99076
Sun R, Sun X, Yang H, Liu Q (2016) Retrospective analysis of serum C-reactive protein/albumin ratio for the prognosis of the adult patients with sepsis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 28(5):413–417
pubmed: 29920034
International Committee for the Classification of Retinopathy of Prematurity (2005) The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol 123(7):991–999. https://doi.org/10.1001/archopht.123.7.991
doi: 10.1001/archopht.123.7.991
Early Treatment For Retinopathy Of Prematurity Cooperative Group (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121(12):1684–1694. https://doi.org/10.1001/archopht.121.12.1684
doi: 10.1001/archopht.121.12.1684
Ingvaldsen SH, Morken TS, Austeng D, Dammann O (2022) Visuopathy of prematurity: is retinopathy just the tip of the iceberg? Pediatr Res 91(5):1043–1048. https://doi.org/10.1038/s41390-021-01625-0
doi: 10.1038/s41390-021-01625-0
pubmed: 34168272
Dammann O (2010) Inflammation and retinopathy of prematurity. Acta Paediatr 99(7):975–977. https://doi.org/10.1111/j.1651-2227.2010.01836.x
doi: 10.1111/j.1651-2227.2010.01836.x
pubmed: 20412106
pmcid: 2902705
Woo SJ, Park KH, Lee SY, Ahn SJ, et al. (2013) The relationship between cord blood cytokine levels and perinatal factors and retinopathy of prematurity: a gestational age-matched case-control study. Invest Ophthalmol Vis Sci 15;54(5):3434–3439. https://doi.org/10.1167/iovs.13-11837
Gessler P, Dahinden C (2013) Increased respiratory burst and increased expression of complement receptor-3 (CD11b/CD18) and of IL-8 receptor-A in neutrophil granulocytes from newborns after vaginal delivery. Biol Neonate 83(2):107–112. https://doi.org/10.1159/000067962
doi: 10.1159/000067962
Dammann O, Brinkhaus MJ, Bartels DB, Dördelmann M et al (2009) Immaturity, perinatal inflammation, and retinopathy of prematurity: a multi-hit hypothesis. Early Human Dev 85(5):325–329. https://doi.org/10.1016/j.earlhumdev.2008.12.010
doi: 10.1016/j.earlhumdev.2008.12.010
Klinger G, Levy I, Sirota L, Boyko V et al, Israel Neonatal Network (2010) Outcome of early-onset sepsis in a national cohort of very low birth weight infants. Pediatrics 125(4):736–740. https://doi.org/10.1542/peds.2009-2017
Chiesa C , Natale F, Pascone R, Osborn JF et al (2011) C reactive protein and procalcitonin: reference intervals for preterm and term newborns during the early neonatal period. Clin Chim Acta 412(11–12):1053–1059. https://doi.org/10.1016/j.cca.2011.02.020
doi: 10.1016/j.cca.2011.02.020
pubmed: 21338596
Ishibashi M, Takemura Y, Ishida H, Watanabe K et al (2002) C-reactive protein kinetics in newborns: application of a high-sensitivity analytic method in its determination. Clin Chem 48(7):1103–1106
doi: 10.1093/clinchem/48.7.1103
pubmed: 12089183
Torer B, Hanta D, Yapakci E, Gokmen Z et al (2016) Association of serum albumin level and mortality in premature infants. J Clin Lab Anal 30(6):867–872. https://doi.org/10.1002/jcla.21949
doi: 10.1002/jcla.21949
pubmed: 27074970
pmcid: 6807091
Akdogan M, Ustundag Y, Cevik SG, Dogan P et al (2016) Correlation between systemic immune-inflammation index and routine hemogram-related inflammatory markers in the prognosis of retinopathy of prematurity. Indian J Ophthalmol 30(6):867–872. https://doi.org/10.4103/ijo.IJO_2745_20
doi: 10.4103/ijo.IJO_2745_20
Kurtul BE, Kabatas EU, Zenciroglu A, Altiaylik Ozer P et al (2015) Serum neutrophil-to-lymphocyte ratio in retinopathy of prematurity. J AAPOS 19(4):327–331. https://doi.org/10.1016/j.jaapos.2015.04.008
doi: 10.1016/j.jaapos.2015.04.008
pubmed: 26239207
Celik K, Ekinci D, Asena M, Okur Matur N (2021) Can hematological parameters be an indicator risk factor in the development of retinopathy of prematurity?? Klin Padiatr 233(05):216–220. https://doi.org/10.1055/a-1289-0105
doi: 10.1055/a-1289-0105
pubmed: 33207376
Juul SE, Haynes JW, McPherson RJ (2004) Evaluation of neutropenia and neutrophilia in hospitalized preterm infants. J Perinatol 24(3):150–157. https://doi.org/10.1038/sj.jp.7211057
doi: 10.1038/sj.jp.7211057
pubmed: 14973510
Walker JC, Smolders MAJC, Gemen EFA, Antonius TAJ et al (2011) Development of lymphocyte subpopulations in preterm infants. Scand J Immunol 73(1):53–58. https://doi.org/10.1111/j.1365-3083.2010.02473.x
doi: 10.1111/j.1365-3083.2010.02473.x
pubmed: 21129003
Said AS, Spinella PC, Hartman ME, Steffen KM et al (2017) RBC distribution width: biomarker for red cell dysfunction and critical illness outcome? Pediatr Crit Care Med 18(2):134–142. https://doi.org/10.1097/PCC.0000000000001017
doi: 10.1097/PCC.0000000000001017
pubmed: 27832023
pmcid: 5291765
Comez A, Yurttutan S, Seringec Akkececi N, Bozkaya A et al (2021) Red cell distribution width and its association with retinopathy of prematurity. Int Ophthalmol 41(2):699–706. https://doi.org/10.1007/s10792-020-01627-7
doi: 10.1007/s10792-020-01627-7
pubmed: 33118094
Italiano JE, Richardson JL, Patel-Hett S, Battinelli E et al (2008) Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 111(3):1227–1233. https://doi.org/10.1182/blood-2007-09-113837
doi: 10.1182/blood-2007-09-113837
pubmed: 17962514
pmcid: 2214735
Sancak S, Toptan HH, Gokmen Yıldırım T, Karatekın G et al (2019) Thrombocytopenıa as a rısk factor for retınopathy of prematurıty. Retina 39(4):706–711. https://doi.org/10.1097/IAE.0000000000002028
doi: 10.1097/IAE.0000000000002028
pubmed: 29370028
Karabulut B, Arcagok BC (2020) New diagnostic possibilities for early onset neonatal sepsis: red cell distribution width to platelet ratio. Fetal Pediatr Pathol 39(4):297–306. https://doi.org/10.1080/15513815.2019.1661051
doi: 10.1080/15513815.2019.1661051
pubmed: 31510842