Metabolism: How a eukaryote adapted to life without respiration.

Eukaryota Respiration

Journal

Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782

Informations de publication

Date de publication:
05 06 2023
Historique:
medline: 8 6 2023
pubmed: 7 6 2023
entrez: 6 6 2023
Statut: ppublish

Résumé

A new study finds that Schizosaccharomyces japonicus, a eukaryote that lost the ability to respire, modified its central carbon metabolism to maintain efficient ATP production, cofactor regeneration, and amino-acid production. This remarkable metabolic flexibility opens new avenues towards applications.

Identifiants

DOI: 10.1016/j.cub.2023.05.002 PMID: 37279666
pubmed: 37279666
pii: S0960-9822(23)00596-1
doi: 10.1016/j.cub.2023.05.002
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

R444-R447

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests K.J.V is a co-inventor on a patent application (WO2020157112A1) that identifies a gene as a major regulator of the Crabtree effect in Saccharomyces cerevisiae. Specifically, the gene regulates the balance between fermentation and respiration. Whereas the topic is related to the submitted manuscript, there is no direct interaction between the two (i.e. nothing written in this piece influences or even directly relates to the patent).

Auteurs

Lloyd Cool (L)

VIB Laboratory for Systems Biology, VIB-KU Leuven Center for Microbiology, Leuven, 3001, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Leuven, 3001, Belgium.

Samuel Hanon (S)

VIB Laboratory for Systems Biology, VIB-KU Leuven Center for Microbiology, Leuven, 3001, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Leuven, 3001, Belgium.

Kevin J Verstrepen (KJ)

VIB Laboratory for Systems Biology, VIB-KU Leuven Center for Microbiology, Leuven, 3001, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Leuven, 3001, Belgium. Electronic address: kevin.verstrepen@kuleuven.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Metabolism: How a eukaryote adapted to life...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Metabolism: How a eukaryote adapted to life...