The Natural Evolution of Nevi with Peripheral Globules.

Humans Adolescent Young Adult Adult Middle Aged Aged Skin Neoplasms / pathology Nevus, Pigmented / pathology Retrospective Studies Dermoscopy / methods Nevus Melanoma / pathology Syndrome
Growth curve Nevus life cycle Peripheral globule nevi

Journal

Dermatology (Basel, Switzerland)
ISSN: 1421-9832
Titre abrégé: Dermatology
Pays: Switzerland
ID NLM: 9203244

Informations de publication

Date de publication:
2023
Historique:
received: 04 01 2023
accepted: 02 05 2023
medline: 23 10 2023
pubmed: 7 6 2023
entrez: 6 6 2023
Statut: ppublish

Résumé

Peripheral globules (PG) in melanocytic lesions represent a concerning dermoscopic feature since they might be present in growing nevi and melanomas. Their natural evolution has not been fully elucidated, and an age-based management approach has been recommended. The aim of this study was to calculate the growth rate of lesions with PG and investigate possible association with age, sex, location, and the global dermoscopic pattern. We retrospectively selected the lesions of interest from a cohort of Caucasian patients who underwent sequential digital dermoscopy monitoring. Lesions with PG distributed at 75% or more of their circumference with available follow-up images or histopathologic report were included. The surface area was automatically calculated with the help of an incorporated tool used in the acquisition of the images. The images were also evaluated by independent investigators for the presence of pre-defined criteria. Growth-curve models were used to assess the growth rate. The outcome variable was the area of nevi in mm2, and scatterplots with Lowess curves were used to present the mean change of nevi during follow-up. A total of 208 lesions from 98 patients with a median age of 36 years (range 15-75) were included. The median follow-up time was 18 months (range 4-48). The mean growth rate for all nevi was 0.16 mm2/month (95% CI, 0.14-0.18, p < 0.001), ranging from -0.29 to 0.61 mm2/month. The growth rate was higher in nevi with a homogeneous dermoscopic pattern (p < 0.001). The number of peripheral globules during follow-up varied from increasing to complete disappearance. None of the lesions developed any melanoma-specific structure at follow-up. Nevi with PG grew at a mean rate of 0.16 mm2/month, and the growth rate was independent of age, gender, or anatomic location. Nevi with homogeneous pattern demonstrated the highest growth rate in our cohort. None of the monitored nevi with PG developed melanoma-specific criteria at follow-up.

Sections du résumé

BACKGROUND BACKGROUND
Peripheral globules (PG) in melanocytic lesions represent a concerning dermoscopic feature since they might be present in growing nevi and melanomas. Their natural evolution has not been fully elucidated, and an age-based management approach has been recommended.
OBJECTIVES OBJECTIVE
The aim of this study was to calculate the growth rate of lesions with PG and investigate possible association with age, sex, location, and the global dermoscopic pattern.
METHODS METHODS
We retrospectively selected the lesions of interest from a cohort of Caucasian patients who underwent sequential digital dermoscopy monitoring. Lesions with PG distributed at 75% or more of their circumference with available follow-up images or histopathologic report were included. The surface area was automatically calculated with the help of an incorporated tool used in the acquisition of the images. The images were also evaluated by independent investigators for the presence of pre-defined criteria. Growth-curve models were used to assess the growth rate. The outcome variable was the area of nevi in mm2, and scatterplots with Lowess curves were used to present the mean change of nevi during follow-up.
RESULTS RESULTS
A total of 208 lesions from 98 patients with a median age of 36 years (range 15-75) were included. The median follow-up time was 18 months (range 4-48). The mean growth rate for all nevi was 0.16 mm2/month (95% CI, 0.14-0.18, p < 0.001), ranging from -0.29 to 0.61 mm2/month. The growth rate was higher in nevi with a homogeneous dermoscopic pattern (p < 0.001). The number of peripheral globules during follow-up varied from increasing to complete disappearance. None of the lesions developed any melanoma-specific structure at follow-up.
CONCLUSION CONCLUSIONS
Nevi with PG grew at a mean rate of 0.16 mm2/month, and the growth rate was independent of age, gender, or anatomic location. Nevi with homogeneous pattern demonstrated the highest growth rate in our cohort. None of the monitored nevi with PG developed melanoma-specific criteria at follow-up.

Identifiants

DOI: 10.1159/000531004 PMID: 37279706
pubmed: 37279706
pii: 000531004
doi: 10.1159/000531004
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

760-767

Informations de copyright

© 2023 S. Karger AG, Basel.

Auteurs

Paula Anca Ilut (PA)

Department of Dermatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Elisa Camela (E)

Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Konstantinos Lallas (K)

Department of Medical Oncology, School of Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece.

Chryssoula Papageorgiou (C)

Second Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece.

Sofia-Magdalini Manoli (SM)

First Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece.

Athanassios Kyrgidis (A)

Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, General Hospital of Thessaloniki "George Papanikolaou,", Thessaloniki, Greece.

Konstantinos Liopyris (K)

Department of Dermatology, University of Athens, Andreas Sygros Hospital for Cutaneous and Venereal Diseases, Athens, Greece.
Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Dimitrios Sgouros (D)

Second Department of Dermatology and Venereology, ATTIKON General University Hospital, Medical School, National and Kapodistrian University, Athens, Greece.

Zoe Apalla (Z)

Second Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece.

Aimilios Lallas (A)

First Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Naevus › Naevus pigmentaire › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Techniques d'investigation › Microscopie intravitale › Dermoscopie › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Naevus › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › The Natural Evolution of Nevi with Peripheral Globules.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Maladie › Syndrome › The Natural Evolution of Nevi with Peripheral Globules.