Submandibular gland involvement in oral cavity squamous cell carcinoma: a retrospective multicenter study.


Journal

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 29 05 2022
accepted: 05 05 2023
medline: 31 7 2023
pubmed: 7 6 2023
entrez: 6 6 2023
Statut: ppublish

Résumé

The submandibular gland (SMG) is routinely excised during neck dissection. Given the importance of the SMG in saliva production, it is important to understand its involvement rate by cancer tissue and the feasibility of its preservation. Retrospective data were collected from five academic centers in Europe. The study involved adult patients affected by primary oral cavity carcinoma (OCC) undergoing tumor excision and neck dissection. The main outcome analyzed was the SMG involvement rate. A systematic review and a meta-analysis were also conducted to provide an updated synthesis of the topic. A total of 642 patients were enrolled. The SMG involvement rate was 12/642 (1.9%; 95% CI 1.0-3.2) when considered per patient, and 12/852 (1.4%; 95% CI 0.6-2.1) when considered per gland. All the glands involved were ipsilateral to the tumor. Statistical analysis showed that predictive factors for gland invasion were: advanced pT status, advanced nodal involvement, presence of extracapsular spread and perivascular invasion. The involvement of level I lymph nodes was associated with gland invasion in 9 out of 12 cases. pN0 cases were correlated with a reduced risk of SMG involvement. The review of the literature and the meta-analysis confirmed the rare involvement of the SMG: on the 4458 patients and 5037 glands analyzed, the involvement rate was 1.8% (99% CI 1.1-2.7) and 1.6% (99% CI 1.0-2.4), respectively. The incidence of SMG involvement in primary OCC is rare. Therefore, exploring gland preservation as an option in selected cases would be reasonable. Future prospective studies are needed to investigate the oncological safety and the real impact on quality of life of SMG preservation.

Sections du résumé

BACKGROUND BACKGROUND
The submandibular gland (SMG) is routinely excised during neck dissection. Given the importance of the SMG in saliva production, it is important to understand its involvement rate by cancer tissue and the feasibility of its preservation.
METHODS METHODS
Retrospective data were collected from five academic centers in Europe. The study involved adult patients affected by primary oral cavity carcinoma (OCC) undergoing tumor excision and neck dissection. The main outcome analyzed was the SMG involvement rate. A systematic review and a meta-analysis were also conducted to provide an updated synthesis of the topic.
RESULTS RESULTS
A total of 642 patients were enrolled. The SMG involvement rate was 12/642 (1.9%; 95% CI 1.0-3.2) when considered per patient, and 12/852 (1.4%; 95% CI 0.6-2.1) when considered per gland. All the glands involved were ipsilateral to the tumor. Statistical analysis showed that predictive factors for gland invasion were: advanced pT status, advanced nodal involvement, presence of extracapsular spread and perivascular invasion. The involvement of level I lymph nodes was associated with gland invasion in 9 out of 12 cases. pN0 cases were correlated with a reduced risk of SMG involvement. The review of the literature and the meta-analysis confirmed the rare involvement of the SMG: on the 4458 patients and 5037 glands analyzed, the involvement rate was 1.8% (99% CI 1.1-2.7) and 1.6% (99% CI 1.0-2.4), respectively.
CONCLUSIONS CONCLUSIONS
The incidence of SMG involvement in primary OCC is rare. Therefore, exploring gland preservation as an option in selected cases would be reasonable. Future prospective studies are needed to investigate the oncological safety and the real impact on quality of life of SMG preservation.

Identifiants

pubmed: 37280380
doi: 10.1007/s00405-023-08007-8
pii: 10.1007/s00405-023-08007-8
pmc: PMC10382344
doi:

Types de publication

Systematic Review Meta-Analysis Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4205-4214

Informations de copyright

© 2023. The Author(s).

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Auteurs

Oreste Iocca (O)

Division of Maxillofacial Surgery, Città della Salute e della Scienza Hospital, University of Torino, Turin, Italy. oreste.iocca@unito.it.

Chiara Copelli (C)

Division of Maxillofacial Surgery, Department of Interdisciplinary Medicine, University of Bari, Bari, Italy.

Paolo Garzino-Demo (P)

Division of Maxillofacial Surgery, Città della Salute e della Scienza Hospital, University of Torino, Turin, Italy.

Guglielmo Ramieri (G)

Division of Maxillofacial Surgery, Città della Salute e della Scienza Hospital, University of Torino, Turin, Italy.

Stefano Rubattino (S)

Division of Maxillofacial Surgery, Città della Salute e della Scienza Hospital, University of Torino, Turin, Italy.

Luca Sedran (L)

Division of Maxillofacial Surgery, Città della Salute e della Scienza Hospital, University of Torino, Turin, Italy.

Fabio Volpe (F)

Division of Maxillofacial Surgery, Città della Salute e della Scienza Hospital, University of Torino, Turin, Italy.

Alfonso Manfuso (A)

Operative Unit of Maxillofacial Surgery, Otolaryngology and Dentistry, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.

Francesco Longo (F)

Operative Unit of Maxillofacial Surgery, Otolaryngology and Dentistry, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.

Gregorio Sanchez-Aniceto (G)

12 de Octubre University Hospital, Av. de Cordoba S/N, 28041, Madrid, Spain.

Álvaro Rivero-Calle (Á)

12 de Octubre University Hospital, Av. de Cordoba S/N, 28041, Madrid, Spain.

Aitor García-Sánchez (A)

Department of Maxillofacial Surgery, Hospital Quiron Salud, Ciudad Real, Spain.

Raul Pellini (R)

Department of Otolaryngology - Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Gerardo Petruzzi (G)

Department of Otolaryngology - Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Silvia Moretto (S)

Department of Otolaryngology - Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Laith Al-Qamachi (L)

Queen's Medical University Hospital, Nottingham, UK.

Hiba Aga (H)

Queen's Medical University Hospital, Nottingham, UK.

Stephen Ridley (S)

Queen's Medical University Hospital, Nottingham, UK.

Pasquale Di Maio (P)

Department of Otolaryngology - Head Neck Surgery, Hospital of Magenta, Milan, Italy.

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