Hyperreflective material in patients with non-neovascular pachychoroid disease.
Age-related macular degeneration
Drusen ooze
Focal choroidal excavation
Hyperreflective foci
Idiopathic choroidal neovascularization
Macular neovascularization
Pachychoroid
Pachychoroid pigment epitheliopathy
Subretinal hyperreflective material
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
06 Jun 2023
06 Jun 2023
Historique:
received:
22
12
2022
accepted:
01
06
2023
medline:
8
6
2023
pubmed:
7
6
2023
entrez:
6
6
2023
Statut:
epublish
Résumé
This study aimed to report eleven cases of non-neovascular pachychoroid disease with hyperreflective material (HRM) that occurred in Japanese patients. A retrospective review of data from eleven patients who had non-neovascular retinal pigment epithelium (RPE) protrusion with HRM in the neurosensory retina between March 2017 and June 2022 was conducted. Clinical examination, color fundus photography, fluorescein angiography, spectral-domain optical coherence tomography (SD-OCT), and OCT angiography data were analyzed. Main outcome measures were patient characteristics, changes in SD-OCT findings, and symptom outcomes. All cases had RPE protrusion and HRM with dilated choroidal veins, which were characteristic of pachychoroid disease. However, none of the cases had macular neovascularization (MNV). In 9 eyes (81.8%), HRM improved spontaneously without intervention and resulted in alterations in RPE, referred to as pachychoroid pigment epitheliopathy (PPE) or focal choroidal excavation (FCE). In these cases, symptoms such as metamorphopsia and distortion improved without treatment. In the remaining two cases (18.2%), HRM still persisted during the follow-up period. There are some cases of non-neovascular pachychoroid disorder with HRM, which might be a new entity of pachychoroid spectrum disease or an early stage of PPE or FCE. These cases should not be misdiagnosed as MNV, and careful observation is necessary.
Sections du résumé
BACKGROUND
BACKGROUND
This study aimed to report eleven cases of non-neovascular pachychoroid disease with hyperreflective material (HRM) that occurred in Japanese patients.
METHODS
METHODS
A retrospective review of data from eleven patients who had non-neovascular retinal pigment epithelium (RPE) protrusion with HRM in the neurosensory retina between March 2017 and June 2022 was conducted. Clinical examination, color fundus photography, fluorescein angiography, spectral-domain optical coherence tomography (SD-OCT), and OCT angiography data were analyzed. Main outcome measures were patient characteristics, changes in SD-OCT findings, and symptom outcomes.
RESULTS
RESULTS
All cases had RPE protrusion and HRM with dilated choroidal veins, which were characteristic of pachychoroid disease. However, none of the cases had macular neovascularization (MNV). In 9 eyes (81.8%), HRM improved spontaneously without intervention and resulted in alterations in RPE, referred to as pachychoroid pigment epitheliopathy (PPE) or focal choroidal excavation (FCE). In these cases, symptoms such as metamorphopsia and distortion improved without treatment. In the remaining two cases (18.2%), HRM still persisted during the follow-up period.
CONCLUSION
CONCLUSIONS
There are some cases of non-neovascular pachychoroid disorder with HRM, which might be a new entity of pachychoroid spectrum disease or an early stage of PPE or FCE. These cases should not be misdiagnosed as MNV, and careful observation is necessary.
Identifiants
pubmed: 37280611
doi: 10.1186/s12886-023-03011-2
pii: 10.1186/s12886-023-03011-2
pmc: PMC10245594
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
255Informations de copyright
© 2023. The Author(s).
Références
Retina. 2015 Jan;35(1):1-9
pubmed: 25158945
Am J Ophthalmol. 2009 Mar;147(3):467-72
pubmed: 19026403
Retina. 2006 Nov-Dec;26(9):1072-6
pubmed: 17151497
Am J Ophthalmol. 2014 Aug;158(2):354-61
pubmed: 24794284
Ophthalmologica. 2013;229(1):32-7
pubmed: 23006969
Retina. 2017 Feb;37(2):199-221
pubmed: 27749784
Retina. 2017 Feb;37(2):316-324
pubmed: 27392097
Retina. 2003 Jun;23(3):288-98
pubmed: 12824827
N Engl J Med. 2006 Oct 5;355(14):1419-31
pubmed: 17021318
Ophthalmologica. 2014;231(1):37-44
pubmed: 24107542
Graefes Arch Clin Exp Ophthalmol. 2012 Aug;250(8):1129-36
pubmed: 22290070
Ophthalmology. 2009 Mar;116(3):488-496.e2
pubmed: 19167082
Am J Ophthalmol. 2012 Aug;154(2):366-375.e4
pubmed: 22633348
Retina. 2010 May;30(5):733-8
pubmed: 20168271
Retina. 2012 Oct;32(9):1829-37
pubmed: 22850219
BMC Ophthalmol. 2014 Nov 20;14:135
pubmed: 25410093
Am J Ophthalmol. 2008 Oct;146(4):496-500
pubmed: 18639219
Ophthalmology. 2020 May;127(5):616-636
pubmed: 31864668
Ophthalmology. 2015 Sep;122(9):1846-53.e5
pubmed: 26143666
Clin Ophthalmol. 2014 Dec 04;8:2461-5
pubmed: 25506207
Retina. 2013 Sep;33(8):1659-72
pubmed: 23751942
Ophthalmology. 2010 Apr;117(4):773-9
pubmed: 20079541
Arch Ophthalmol. 2011 Oct;129(10):1320-5
pubmed: 21670327
Ophthalmology. 2009 May;116(5):914-20
pubmed: 19410950
Ophthalmol Retina. 2017 Nov - Dec;1(6):461-473
pubmed: 31047436
Retina. 2012 Jan;32(1):77-85
pubmed: 21866075
Retina. 2016 Jan;36(1):1-8
pubmed: 26414957
Eye (Lond). 2019 Jan;33(1):14-33
pubmed: 29995841
Retina. 2014 Jul;34(7):1281-8
pubmed: 24695062
Retina. 2013 Jun;33(6):1201-10
pubmed: 23514801
Ophthalmology. 2015 Jul;122(7):1534-5
pubmed: 25687028
JAMA Ophthalmol. 2015 Jan;133(1):45-50
pubmed: 25317632
Sci Rep. 2019 Apr 3;9(1):5565
pubmed: 30944393