Cefquinome shows a higher impact on the pig gut microbiome and resistome compared to ceftiofur.
16S rRNA sequencing
ARGs
Veterinary cephalosporins
gut microbiome
metagenomics
porcine feces
resistome
shotgun sequencing
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
06 Jun 2023
06 Jun 2023
Historique:
received:
17
02
2023
accepted:
10
05
2023
medline:
8
6
2023
pubmed:
7
6
2023
entrez:
6
6
2023
Statut:
epublish
Résumé
Cephalosporins are licensed for treatment of severe bacterial infections in different species. However, the effect of these antimicrobials on the fecal microbiome and potential spread of resistance-associated genes causes great concern. This highlights the need to understand the impact of cephalosporins on the porcine fecal microbiome and resistome. A combination of long-read 16S rRNA gene and shotgun metagenomic sequencing was applied to investigate the effect of conventional treatment with either ceftiofur (3 mg.kg
Identifiants
pubmed: 37280708
doi: 10.1186/s13567-023-01176-8
pii: 10.1186/s13567-023-01176-8
pmc: PMC10242799
doi:
Substances chimiques
ceftiofur
83JL932I1C
cefquinome
Z74S078CWP
Anti-Bacterial Agents
0
RNA, Ribosomal, 16S
0
Cephalosporins
0
Anti-Infective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
45Informations de copyright
© 2023. The Author(s).
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