Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players.

Humans Male Adult Middle Aged Football Chronic Traumatic Encephalopathy / pathology Brain / pathology Brain Concussion / pathology Positron-Emission Tomography Amyloid beta-Peptides tau Proteins / metabolism
FTP PET TBI concussion football

Journal

Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626

Informations de publication

Date de publication:
08 2023
Historique:
medline: 21 8 2023
pubmed: 7 6 2023
entrez: 7 6 2023
Statut: ppublish

Résumé

American-style football (ASF) players experience repetitive head impacts that may result in chronic traumatic encephalopathy neuropathological change (CTE-NC). At present, a definitive diagnosis of CTE-NC requires the identification of localized hyperphosphorylated Tau (p-Tau) after death via immunohistochemistry. Some studies suggest that positron emission tomography (PET) with the radiotracer [

Identifiants

DOI: 10.1089/neu.2022.0454 PMID: 37282582 PMC: PMC10458363
pubmed: 37282582
doi: 10.1089/neu.2022.0454
pmc: PMC10458363
doi:

Substances chimiques

Amyloid beta-Peptides 0
tau Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1614-1624

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Auteurs

Maeva Dhaynaut (M)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Rachel Grashow (R)

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.

Marc D Normandin (MD)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Ona Wu (O)

Athinoula A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

Dean Marengi (D)

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.

Douglas P Terry (DP)

Vanderbilt Sports Concussion Center, Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Justin S Sanchez (JS)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Marc G Weisskopf (MG)

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.

Frank E Speizer (FE)

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachsetts, USA.

Herman A Taylor (HA)

Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Morehouse School of Medicine, Atlanta, Georgia, USA.

Nicolas J Guehl (NJ)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Sudha Seshadri (S)

The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UTHSA, San Antonio, Texas, USA.

Alexa Beiser (A)

NHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.
Department of Biostatistics and Neurology, Boston University School of Public Health, Boston, Massachusetts, USA.

Daniel H Daneshvar (DH)

Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts 02129, USA.

Keith Johnson (K)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Grant L Iverson (GL)

Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts 02129, USA.
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Charlestown, Massachusetts, USA.
Department of Physical Medicine and Rehabilitation, Schoen Adams Research Institute at Spaulding Rehabilitation, Charlestown, Massachusetts, USA.
Sports Concussion Program, MassGeneral Hospital for Children, Boston, Massachusetts, USA.

Ross Zafonte (R)

Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts 02129, USA.
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Charlestown, Massachusetts, USA.

Georges El Fakhri (G)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Aaron L Baggish (AL)

Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Cardiology, Lausanne University Hospital (CHUV) and Institute for Sport Science, University of Lausanne (ISSUL), Lausanne, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tau Positron Emission Tomography and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Tau Positron Emission Tomography and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Tau Positron Emission Tomography and...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Loisir › Sports › Football américain › Tau Positron Emission Tomography and...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Souffrance cérébrale chronique post-traumatique › Encéphalopathie traumatique chronique › Tau Positron Emission Tomography and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tau Positron Emission Tomography and...
questionsmedicales.fr › Plaies et blessures › Plaies non pénétrantes › Traumatismes crâniens fermés › Commotion de l'encéphale › Tau Positron Emission Tomography and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tau Positron Emission Tomography and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Tau Positron Emission Tomography and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Tau Positron Emission Tomography and...