A pilot study evaluating the use of sirolimus in children and young adults with desmoid-type fibromatosis.

children desmoid tumor sirolimus young adults

Journal

Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624

Informations de publication

Date de publication:
07 Jun 2023
Historique:
revised: 15 04 2023
received: 07 03 2023
accepted: 08 05 2023
pubmed: 7 6 2023
medline: 7 6 2023
entrez: 7 6 2023
Statut: aheadofprint

Résumé

Deregulation of the mTOR pathway may play an important role in tumor biology when the APC/β-catenin pathway is disrupted in desmoid-type fibromatosis (DT). A pilot study was conducted to determine whether sirolimus can block the mTOR pathway (primary aim) as well as determine whether it can safely be given in the preoperative setting, decrease tumor size/recurrence, and decrease tumor-associated pain in children and young adults (secondary aims) with DT. Nine subjects ages 5-28 years were enrolled from 2014 to 2017 across four centers. Sirolimus was feasible and was associated with a nonstatistically significant decrease in pS706K activation.

Identifiants

pubmed: 37283290
doi: 10.1002/pbc.30466
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e30466

Subventions

Organisme : Desmoid Tumor Research Foundation
Organisme : Pfizer

Informations de copyright

© 2023 Wiley Periodicals LLC.

Références

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Auteurs

Aaron R Weiss (AR)

Division of Hematology/Oncology, Department of Pediatrics, Maine Medical Center, Portland, Maine, USA.

Sarah Dry (S)

Department of Pathology Bone, Soft Tissue and GI Pathology, University of California Los Angeles, Los Angeles, California, USA.

Clara Maygar (C)

Department of Pathology Bone, Soft Tissue and GI Pathology, University of California Los Angeles, Los Angeles, California, USA.

Anya Cutler (A)

MaineHealth Institute for Research, Portland, Maine, USA.

Christine W Lary (CW)

Roux Institute and the Bouve College of Health Sciences at Northeastern University, Portland, Maine, USA.

Carmen Khoo (C)

MaineHealth Institute for Research, Portland, Maine, USA.

Jillian E Fergione (JE)

Division of Hematology/Oncology, Department of Pediatrics, Maine Medical Center, Portland, Maine, USA.

Melanie M Hounchell (MM)

Division of Hematology/Oncology, Department of Pediatrics, Maine Medical Center, Portland, Maine, USA.

Kathleen Glick (K)

Division of Hematology/Oncology, Department of Pediatrics, Maine Medical Center, Portland, Maine, USA.

Meghen Browning (M)

Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA.

Sun Ha Choo (SH)

Division of Hematology/Oncology, Department of Pediatrics, Rady Children's Hospital, San Diego, California, USA.

Douglas S Hawkins (DS)

Division of Hematology/Oncology, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.

Joanne Lagmay (J)

Division of Hematology/Oncology, Department of Pediatrics, University of Florida Health Science Center, Gainesville, Florida, USA.

Michelle Manalang (M)

Department of Pediatrics, Marshfield Marshfield Medical Center, Marshfield, Wisconsin, USA.

Stephen X Skapek (SX)

Division of Hematology/Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Brenda Weigel (B)

Division of Hematology/Oncology, Department of Pediatrics, University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, USA.

Stephanie Verwys (S)

Division of Hematology/Oncology, Department of Pediatrics, Maine Medical Center, Portland, Maine, USA.

Noah Federman (N)

Departments of Pediatrics and Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.

Classifications MeSH