Associations of Gestational Perfluoroalkyl Substances Exposure with Early Childhood BMI

Male Pregnancy Female Adolescent Humans Child, Preschool Child Body Mass Index Overweight / epidemiology Prospective Studies Bayes Theorem Obesity / chemically induced Fluorocarbons Environmental Pollutants Alkanesulfonic Acids

Journal

Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411

Informations de publication

Date de publication:
06 2023
Historique:
medline: 9 6 2023
pubmed: 7 6 2023
entrez: 7 6 2023
Statut: ppublish

Résumé

Gestational per- and polyfluoroalkyl substances (PFAS) exposure may be associated with adiposity and increased risk of obesity among children and adolescents. However, results from epidemiological studies evaluating these associations are inconsistent. We estimated the associations of pregnancy PFAS concentrations with child body mass index (BMI) We used data from 1,391 mother-child pairs who enrolled in eight Environmental influences on Child Health Outcomes (ECHO) cohorts (enrolled: 1999-2019). We quantified concentrations of seven PFAS in maternal plasma or serum in pregnancy. We measured child weight and height between the ages of 2 and 5 y and calculated age- and sex-specific BMI We observed a pattern of subtle positive associations of PFAS concentrations in pregnancy with BMI In eight U.S.-based prospective cohorts, gestational exposure to higher levels of PFAS were associated with slightly higher childhood BMI

Sections du résumé

BACKGROUND
Gestational per- and polyfluoroalkyl substances (PFAS) exposure may be associated with adiposity and increased risk of obesity among children and adolescents. However, results from epidemiological studies evaluating these associations are inconsistent.
OBJECTIVES
We estimated the associations of pregnancy PFAS concentrations with child body mass index (BMI)
METHODS
We used data from 1,391 mother-child pairs who enrolled in eight Environmental influences on Child Health Outcomes (ECHO) cohorts (enrolled: 1999-2019). We quantified concentrations of seven PFAS in maternal plasma or serum in pregnancy. We measured child weight and height between the ages of 2 and 5 y and calculated age- and sex-specific BMI
RESULTS
We observed a pattern of subtle positive associations of PFAS concentrations in pregnancy with BMI
DISCUSSION
In eight U.S.-based prospective cohorts, gestational exposure to higher levels of PFAS were associated with slightly higher childhood BMI

Identifiants

DOI: 10.1289/EHP11545 PMID: 37283528 PMC: PMC10246497
pubmed: 37283528
doi: 10.1289/EHP11545
pmc: PMC10246497
doi:

Substances chimiques

Fluorocarbons 0
Environmental Pollutants 0
Alkanesulfonic Acids 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

67001

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Yun Liu (Y)

Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.
ORCID: 0000-0002-2979-9552

Adaeze C Wosu (AC)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Abby F Fleisch (AF)

Pediatric Endocrinology and Diabetes, Maine Medical Center and Maine Medical Center Research Institute, Portland, Maine, USA.
Center for Outcomes Research and Evaluation, Maine Medical Center and Maine Medical Center Research Institute, Portland, Maine, USA.

Anne L Dunlop (AL)

Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA.

Anne P Starling (AP)

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Assiamira Ferrara (A)

Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

Dana Dabelea (D)

Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Emily Oken (E)

Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

Jessie P Buckley (JP)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Leda Chatzi (L)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Margaret R Karagas (MR)

Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.

Megan E Romano (ME)

Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.

Susan Schantz (S)

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Thomas G O'Connor (TG)

Department of Psychiatry, University of Rochester, Rochester, New York, USA.

Tracey J Woodruff (TJ)

Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.

Yeyi Zhu (Y)

Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Ghassan B Hamra (GB)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Joseph M Braun (JM)

Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Apparence corporelle › Surpoids › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Théorème de Bayes › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures fluorés › Fluorocarbones › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Associations of Gestational Perfluoroalkyl...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfoniques › Acides alcanesulfoniques › Associations of Gestational Perfluoroalkyl...