Exercise elevates serum brain-derived neurotrophic factor in partially remitted depression.

Adult Humans Brain-Derived Neurotrophic Factor Depression Depressive Disorder, Major Exercise Exercise Therapy
Biomarkers Blood serum Physical activity

Journal

Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385

Informations de publication

Date de publication:
08 2023
Historique:
received: 26 01 2023
revised: 31 05 2023
accepted: 02 06 2023
medline: 23 10 2023
pubmed: 7 6 2023
entrez: 7 6 2023
Statut: ppublish

Résumé

Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven participants with partially remitted MDD were allocated to either a bout of strenuous or light activity. Serum was collected before and after the intervention. BDNF was measured using a highly sensitive and specific enzyme-linked immunosorbent assay. Significant BDNF elevation in the strenuous activity group emerged. This study confirms exercise-dependent serum BDNF elevation in MDD. Preregistration: German Clinical Trials Register (DRKS0001515).

Identifiants

DOI: 10.1016/j.psychres.2023.115283 PMID: 37285622
pubmed: 37285622
pii: S0165-1781(23)00233-0
doi: 10.1016/j.psychres.2023.115283
pii:
doi:

Substances chimiques

Brain-Derived Neurotrophic Factor 0

Banques de données

DRKS
['DRKS0001515']

Types de publication

Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

115283

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors declare no competing interests.

Auteurs

Benedikt Alexander Kramer (BA)

Research Group Neurocognition, Department of General Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Voßstraße 4, Heidelberg 69115, Germany. Electronic address: benediktalexander.kramer@med.uni-heidelberg.de.

Anna Jaehn (A)

Research Group Neurocognition, Department of General Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Voßstraße 4, Heidelberg 69115, Germany.

Thea Marianne Grützner (TM)

Research Group Neurocognition, Department of General Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Voßstraße 4, Heidelberg 69115, Germany.

Natalie Sarah Hess (NS)

Research Group Neurocognition, Department of General Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Voßstraße 4, Heidelberg 69115, Germany.

Amanda Bellanti (A)

Research Group Neurocognition, Department of General Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Voßstraße 4, Heidelberg 69115, Germany.

Lena Listunova (L)

Research Group Neurocognition, Department of General Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Voßstraße 4, Heidelberg 69115, Germany.

Rainer Hellweg (R)

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Berlin, Germany.

Matthias Weisbrod (M)

Research Group Neurocognition, Department of General Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Voßstraße 4, Heidelberg 69115, Germany; Department of Psychiatry and Psychotherapy, SRH Hospital Karlsbad-Langensteinbach, Guttmannstraße 1, Karlsbad 76307, Germany.

Daniela Roesch Ely (D)

Research Group Neurocognition, Department of General Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Voßstraße 4, Heidelberg 69115, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Exercise elevates serum brain-derived...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exercise elevates serum brain-derived...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Exercise elevates serum brain-derived...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Exercise elevates serum brain-derived...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Exercise elevates serum brain-derived...
questionsmedicales.fr › Activités humaines › Exercice physique › Exercise elevates serum brain-derived...
questionsmedicales.fr › Thérapeutique › Techniques de physiothérapie › Traitement par les exercices physiques › Exercise elevates serum brain-derived...