Human Papilloma Virus DNA Detection in Clinical Samples Using Fluorogenic Probes Based on Oligonucleotide Gated Nanoporous Anodic Alumina Films.

biosensors clinical validations gated nanoporous anodic alumina high-risk human papilloma virus oligonucleotides

Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
09 2023
Historique:
revised: 19 04 2023
received: 20 12 2022
medline: 4 9 2023
pubmed: 8 6 2023
entrez: 7 6 2023
Statut: ppublish

Résumé

In this work, fluorogenic probes based on oligonucleotide capped nanoporous anodic alumina films are developed for specific and sensitive detection of human papilloma virus (HPV) DNA. The probe consists of anodic alumina nanoporous films loaded with the fluorophore rhodamine B (RhB) and capped with oligonucleotides bearing specific base sequences complementary to genetic material of different high-risk (hr) HPV types. Synthesis protocol is optimized for scale up production of sensors with high reproducibility. The sensors' surfaces are characterized by scanning electron microscopy (HR-FESEM) and atomic force microscopy (AFM) and their atomic composition is determined by energy dispersive X-ray spectroscopy (EDXS). Oligonucleotide molecules onto nanoporous films block the pores and avoid diffusion of RhB to the liquid phase. Pore opening is produced when specific DNA of HPV is present in the medium, resulting in RhB delivery, that is detected by fluorescence measurements. The sensing assay is optimized for reliable fluorescence signal reading. Nine different sensors are synthesized for specific detection of 14 different hr-HPV types in clinical samples with very high sensitivity (100%) and high selectivity (93-100%), allowing rapid screening of virus infections with very high negative predictive values (100%).

Identifiants

pubmed: 37285852
doi: 10.1002/adhm.202203326
doi:

Substances chimiques

Aluminum Oxide LMI26O6933
Oligonucleotides 0
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2203326

Informations de copyright

© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.

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Auteurs

Andy Hernández-Montoto (A)

The Inter-University Research Institute for Molecular Recognition and Technological Development, Technical University of Valencia, University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
CIBER Bioengineering, Biomaterials and Nanomedicine, Carlos III Health Institute, Avenida Monforte de Lemos 3-5, Madrid, 28029, Spain.
Joint Research Unit in Nanomedicine and Sensors, Health Research Institute Hospital La Fe, Technical University of Valencia, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.

M Nieves Aranda (MN)

The Inter-University Research Institute for Molecular Recognition and Technological Development, Technical University of Valencia, University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
Joint Research Unit in Nanomedicine and Sensors, Health Research Institute Hospital La Fe, Technical University of Valencia, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.

Isabel Caballos (I)

The Inter-University Research Institute for Molecular Recognition and Technological Development, Technical University of Valencia, University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
Joint Research Unit in Nanomedicine and Sensors, Health Research Institute Hospital La Fe, Technical University of Valencia, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.

Alba López-Palacios (A)

The Inter-University Research Institute for Molecular Recognition and Technological Development, Technical University of Valencia, University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
Joint Research Unit in Nanomedicine and Sensors, Health Research Institute Hospital La Fe, Technical University of Valencia, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.

María Ángeles Tormo-Mas (MÁ)

Accredited Research Group on Serious Infection, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.

Javier Pemán (J)

Accredited Research Group on Serious Infection, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.
Microbiology Service, Polytechnic and University Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.

Mireya Prieto Rodríguez (MP)

Pathological Anatomy Service, Polytechnic and University Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.

Carlos Picornell (C)

Arafarma Group, C/ Fray Gabriel de San Antonio, 6-10, Marchamalo, 19180, Guadalajara, Spain.

Elena Aznar (E)

The Inter-University Research Institute for Molecular Recognition and Technological Development, Technical University of Valencia, University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
CIBER Bioengineering, Biomaterials and Nanomedicine, Carlos III Health Institute, Avenida Monforte de Lemos 3-5, Madrid, 28029, Spain.
Joint Research Unit in Nanomedicine and Sensors, Health Research Institute Hospital La Fe, Technical University of Valencia, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.
UPV-CIPF Joint Research Unit in Mechanisms of Diseases and Nanomedicine, Valencia, Technical University of Valencia, València, 46012, Spain.

Ramón Martínez-Máñez (R)

The Inter-University Research Institute for Molecular Recognition and Technological Development, Technical University of Valencia, University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
CIBER Bioengineering, Biomaterials and Nanomedicine, Carlos III Health Institute, Avenida Monforte de Lemos 3-5, Madrid, 28029, Spain.
Joint Research Unit in Nanomedicine and Sensors, Health Research Institute Hospital La Fe, Technical University of Valencia, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain.
UPV-CIPF Joint Research Unit in Mechanisms of Diseases and Nanomedicine, Valencia, Technical University of Valencia, València, 46012, Spain.

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