Diverse diterpenoids from Callicarpa rubella Lindl. as natural inhibitors of macrophage foam cell formation.

Abietanes / chemistry Callicarpa / chemistry Foam Cells Molecular Structure Plant Leaves / chemistry Diterpenes / chemistry Macrophages Rubella / metabolism
Anti-atherosclerosis activity Callicarpa rubella Diterpenoid Lamiaceae Pimarane

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 07 03 2023
revised: 29 05 2023
accepted: 31 05 2023
medline: 4 8 2023
pubmed: 8 6 2023
entrez: 7 6 2023
Statut: ppublish

Résumé

Ten undescribed diterpenoids namely rubellawus E-N of structural types pimarane (1, 3-4), nor-abietane (2), nor-pimarane (5-6), isopimarane (7-9), and nor-isopimarane (10), along with eleven known compounds, were isolated and identified from the aerial parts of Callicarpa rubella Lindl. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analyses and quantum chemical computations. Pharmacologically, almost all the compounds exhibited a potential inhibitory effect on oxidized low-density lipoprotein-induced macrophage foam cell formation, which suggests that these compounds may be promising candidates in the treatment of atherosclerosis.

Identifiants

DOI: 10.1016/j.phytochem.2023.113748 PMID: 37286023
pubmed: 37286023
pii: S0031-9422(23)00164-4
doi: 10.1016/j.phytochem.2023.113748
pii:
doi:

Substances chimiques

Abietanes 0
Diterpenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113748

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Xue-Wen Wu (XW)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Qian-Lang Feng (QL)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Yi-Fan Xie (YF)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Si-Chen Song (SC)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Bin Cheng (B)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Yan Ma (Y)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Qing Li (Q)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Xu Ji (X)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Xiao-Li Li (XL)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, PR China. Electronic address: lixiaoli@ynu.edu.cn.

Guang Cao (G)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China. Electronic address: caoguang@ynu.edu.cn.

Wei-Lie Xiao (WL)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, PR China. Electronic address: xiaoweilie@ynu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Diterpènes de type abiétane › Diverse diterpenoids from Callicarpa rubella...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Lamiaceae › Callicarpa › Diverse diterpenoids from Callicarpa rubella...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Cellules spumeuses › Diverse diterpenoids from Callicarpa rubella...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Diverse diterpenoids from Callicarpa rubella...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › Diverse diterpenoids from Callicarpa rubella...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Diverse diterpenoids from Callicarpa rubella...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Diverse diterpenoids from Callicarpa rubella...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Togaviridae › Infections à rubivirus › Rubéole › Diverse diterpenoids from Callicarpa rubella...