PlmCas12e (CasX2) cleavage of CCR5: impact of guide RNA spacer length and PAM sequence on cleavage activity.
CCR5
CasX2
Crispr/Cas
Guide RNA
PAM requirements
Journal
RNA biology
ISSN: 1555-8584
Titre abrégé: RNA Biol
Pays: United States
ID NLM: 101235328
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
medline:
9
6
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas9 systems from
Identifiants
pubmed: 37287312
doi: 10.1080/15476286.2023.2221510
pmc: PMC10251783
doi:
Substances chimiques
RNA
63231-63-0
Nucleotides
0
CCR5 protein, human
0
Receptors, CCR5
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
296-305Subventions
Organisme : BLRD VA
ID : I01 BX005248
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK117469
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023108
Pays : United States
Commentaires et corrections
Type : UpdateOf
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