A novel calorimeter for synchrotron produced monochromatic x-ray beams.


Journal

Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746

Informations de publication

Date de publication:
Oct 2023
Historique:
revised: 12 03 2023
received: 08 11 2022
accepted: 05 05 2023
medline: 23 10 2023
pubmed: 8 6 2023
entrez: 8 6 2023
Statut: ppublish

Résumé

Electron synchrotrons produce x-ray beams with dose rates orders of magnitude greater than conventional x-ray tubes and with beam sizes on the order of a few millimeters. These characteristics put severe challenges on current dosimeters to accurately realize absorbed dose or air kerma. This work seeks to investigate the suitability of a novel aluminum-based calorimeter to determine absorbed dose to water with an uncertainty significantly smaller than currently possible with conventional detectors. A lower uncertainty in the determination of absolute dose rate would impact both therapeutic applications of synchrotron-produced x-ray beams and research investigations. A vacuum-based calorimeter prototype with an aluminum core was built, matching the beam profile of the 140 keV monochromatic x-ray beam, produced by the Canadian Light Source Biomedical Imaging and Therapy beamline. The choice of material and overall calorimeter design was optimized using FEM thermal modeling software while Monte Carlo radiation transport simulations were used to model the impact of interactions of the radiation beam with the detector components. Corrections for both the thermal conduction and radiation transport effects were of the order of 3% and the simplicity of the geometry, combined with the monochromatic nature of the incident x-ray beam, meant that the uncertainty in each correction was ≤0.5%. The calorimeter performance was found to be repeatable over multiple irradiations of 1 Gy at the ± 0.6% level, and no systematic dependence on environmental effects or total dose was observed. The combined standard uncertainty in the determination of absorbed dose to aluminum was estimated to be 0.8%, indicating that absorbed dose to water, the ultimate quantity of interest, could be determined with an uncertainty on the order of 1%. This value is an improvement over current techniques used for synchrotron dosimetry and comparable with the state-of-the art for conventional kV x-ray dosimetry.

Sections du résumé

BACKGROUND BACKGROUND
Electron synchrotrons produce x-ray beams with dose rates orders of magnitude greater than conventional x-ray tubes and with beam sizes on the order of a few millimeters. These characteristics put severe challenges on current dosimeters to accurately realize absorbed dose or air kerma.
PURPOSE OBJECTIVE
This work seeks to investigate the suitability of a novel aluminum-based calorimeter to determine absorbed dose to water with an uncertainty significantly smaller than currently possible with conventional detectors. A lower uncertainty in the determination of absolute dose rate would impact both therapeutic applications of synchrotron-produced x-ray beams and research investigations.
METHODS METHODS
A vacuum-based calorimeter prototype with an aluminum core was built, matching the beam profile of the 140 keV monochromatic x-ray beam, produced by the Canadian Light Source Biomedical Imaging and Therapy beamline. The choice of material and overall calorimeter design was optimized using FEM thermal modeling software while Monte Carlo radiation transport simulations were used to model the impact of interactions of the radiation beam with the detector components.
RESULTS RESULTS
Corrections for both the thermal conduction and radiation transport effects were of the order of 3% and the simplicity of the geometry, combined with the monochromatic nature of the incident x-ray beam, meant that the uncertainty in each correction was ≤0.5%. The calorimeter performance was found to be repeatable over multiple irradiations of 1 Gy at the ± 0.6% level, and no systematic dependence on environmental effects or total dose was observed.
CONCLUSION CONCLUSIONS
The combined standard uncertainty in the determination of absorbed dose to aluminum was estimated to be 0.8%, indicating that absorbed dose to water, the ultimate quantity of interest, could be determined with an uncertainty on the order of 1%. This value is an improvement over current techniques used for synchrotron dosimetry and comparable with the state-of-the art for conventional kV x-ray dosimetry.

Identifiants

pubmed: 37287315
doi: 10.1002/mp.16526
doi:

Substances chimiques

Aluminum CPD4NFA903
Water 059QF0KO0R

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6543-6553

Informations de copyright

© 2023 His Majesty the King in Right of Canada. Medical Physics © 2023 American Association of Physicists in Medicine. Reproduced with the permission of the Minister of Innovation, Science And Economic Development Canada.

Références

Anderson DL. Dosimetry and Biological Studies for Microbeam Radiation Therapy at the Canadian Light Source. Published online 2015. doi:10.7939/R3N29PC3H
Bräuer-Krisch E, Serduc R, Siegbahn EA, et al. Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue. Mutat Res Rev Mutat Res. 2010;704(1-3):160-166. doi:10.1016/J.MRREV.2009.12.003
Grotzer MA, Schültke E, Bräuer-Krisch E, Laissue JA. Microbeam radiation therapy: clinical perspectives. Phys Med. 2015;31(6):564-567. doi:10.1016/J.EJMP.2015.02.011
Laissue JA, Bartzsch S, Blattmann H, et al. Response of the rat spinal cord to X-ray microbeams. Radiother Oncol. 2013;106(1):106-111. doi:10.1016/J.RADONC.2012.12.007
Prezado Y, Vautrin M, Martínez-Rovira I, et al. Dosimetry protocol for the forthcoming clinical trials in synchrotron stereotactic radiation therapy (SSRT). Med Phys. 2011;38(3):1709-1717. doi:10.1118/1.3556561
Laissue JA, Blattmann H, di Michiel M. Weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology. In: Barber HB, Roehrig H, Doty FP, Schirato RC, Morton EJ, eds. Penetrating Radiation Systems and Applications III. SPIE; 2001:65-73. doi:10.1117/12.450774
Régnard P, Bräuer-Krisch E, Troprès I, Keyriläinen J, Bravin A, le Duc G. Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy. Eur J Radiol. 2008;68(3):S151-S155. doi:10.1016/J.EJRAD.2008.04.049
Slatkin DN, Spanne P, Dilmanian FA, Gebbers JO, Laissue JA. Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler. Proc Natl Acad Sci U S A. 1995;92(19):8783-8787. doi:10.1073/pnas.92.19.8783
van Elzen den P, Sander T, Palmans H, et al. Alanine response to low energy synchrotron x-ray radiation. Phys Med Biol. doi:10.1088/1361-6560/ACB886. Published online February 2, 2023.
Anton M, Büermann L. Relative response of the alanine dosimeter to medium energy x-rays. Phys Med Biol. 2015;60(15):6113-6129. doi:10.1088/0031-9155/60/15/6113
McEwen M, el Gamal I, Mainegra-Hing E, Cojocaru C. Determination of the Radiation Chemical Yield (G) for the Fricke Chemical Dosimetry System in Photon and Electron Beams. National Research Council of Canada. Measurement Science and Standards; 2014. doi:10.4224/23002718
Bräuer-Krisch E, Adam JF, Alagoz E, et al. Medical physics aspects of the synchrotron radiation therapies: microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT). Physica Medica. 2015;31(6):568-583. doi:10.1016/J.EJMP.2015.04.016
Hermida-López M, Lüdemann L, Flühs A, Brualla L. Technical Note: influence of the phantom material on the absorbed-dose energy dependence of the EBT3 radiochromic film for photons in the energy range 3 keV-18 MeV. Med Phys. 2014;41(11):112103. doi:10.1118/1.4898598
Siegbahn EA, Bräuer-Krisch E, Bravin A, Nettelbeck H, Lerch MLF, Rosenfeld AB. MOSFET dosimetry with high spatial resolution in intense synchrotron-generated x-ray microbeams. Med Phys. 2009;36(4):1128-1137. doi:10.1118/1.3081934
Absorbed Dose Determination in External Beam Radiotherapy. International Atomic Energy Agency; 2001. https://www.iaea.org/publications/5954/absorbed-dose-determination-in-external-beam-radiotherapy
Renaud J, Palmans H, Sarfehnia A, Seuntjens J. Absorbed dose calorimetry. Phys Med Biol. 2020;65(5):05TR02. doi:10.1088/1361-6560/AB4F29
Rapp B, Perichon N, Denoziere M, Daures J, Ostrowsky A, Bordy JM. The LNE-LNHB water calorimeter for primary measurement of absorbed dose at low depth in water: application to medium-energy x-rays. Phys Med Biol. 2013;58(9):2769. doi:10.1088/0031-9155/58/9/2769
Lye JE, Harty PD, Butler DJ, et al. Absolute dosimetry on a dynamically scanned sample for synchrotron radiotherapy using graphite calorimetry and ionization chambers. Phys Med Biol. 2016;61(11):4201. doi:10.1088/0031-9155/61/11/4201
Bass GA, Shipley DR, Flynn SF, Thomas RAS. A prototype low-cost secondary standard calorimeter for reference dosimetry with ultra-high pulse dose rates. Br J Radiol. 2023;96(1141). doi:10.1259/BJR.20220638/ASSET/IMAGES/LARGE/BJR.20220638.G009.JPEG
Bourgouin A. Determination of Wair Value in High Energy Electron Beam. Carleton University; 2020.
Ali ESM, Spencer B, McEwen MR, Rogers DWO. Towards a quantitative, measurement-based estimate of the uncertainty in photon mass attenuation coefficients at radiation therapy energies. Phys Med Biol. 2015;60(4):1641. doi:10.1088/0031-9155/60/4/1641
Hochäuser E, Balk OA. A foil calorimeter for dosimetry of short impulse electron radiation of high dose rate. Nucl Instrum Methods Phys Res A. 1988;263(2-3):493-498. doi:10.1016/0168-9002(88)90992-8
Szpala S, Renaud J, Muir BR, Bourgouin A, Kohli K, McEwen M. Calorimeter measurements of absolute dose in aluminum, a surrogate of bone, to validate dose-to-medium in Acuros XB. Phys Med Biol. 2022;68(1). doi:10.1088/1361-6560/ACA869
Bourgouin A, Schüller A, Hackel T, et al. Calorimeter for real-time dosimetry of pulsed ultra-high dose rate electron beams. Front Phys. 2020;8:400. doi:10.3389/FPHY.2020.567340/BIBTEX
BMIT - Beamlines Specifications. Accessed April 26, 2022. https://bmit.lightsource.ca/tech-info/Beamlines-Specifications/
Desai PD. Thermodynamic properties of aluminum. Int J Thermophys. 1987;8(5):621-638. doi:10.1007/BF00503647/METRICS
Giauque WF, Meads PF. The heat capacities and entropies of aluminum and copper from 15 to 300°k. J Am Chem Soc. 1941;63(7):1897-1901. doi:10.1021/JA01852A027/ASSET/JA01852A027.FP.PNG_V03
Ditmars DA, Plint CA, Shukla RC. Aluminum. I. Measurement of the relative enthalpy from 273 to 929 K and derivation of thermodynamic functions for Al(s) from 0 K to Its melting point. Int J Thermophys. 1985;6(5):499-515. doi:10.1007/BF00508893/METRICS
Buyco EH, Davis FE. Specific heat of aluminum from zero to its melting temperature and beyond equation for representation of the specific heat of solids. J Chem Eng Data. 1970;15(4):518-523. doi:10.1021/JE60047A035/ASSET/JE60047A035.FP.PNG_V03
Downie DB, Martin JF. An adiabatic calorimeter for heat-capacity measurements between 6 and 300 K. The molar heat capacity of aluminium. J Chem Thermodyn. 1980;12(8):779-786. doi:10.1016/0021-9614(80)90176-7
Domen SR, Lamperti PJ. A heat-loss-compensated calorimeter: theory, design, and performance. J Res Natl Bur Stand A Phys Chem. 1974;78A(5):595. doi:10.6028/JRES.078A.037
McEwen MR. Development of a Portable Graphite Calorimeter for Measuring Absorbed Dose in the Radiotherapy Clinic. University of Surrey; 2002.
BuyAerogel.com | Airloy® X116 Non-Flammable Strong Aerogel Tiles. Accessed April 26, 2022. http://www.buyaerogel.com/product/airloy-x116/
Nickel 200 Alloy (UNS N02200). Accessed March 5, 2023. https://www.azom.com/article.aspx?ArticleID=9283
Seuntjens J, Duane S. Photon absorbed dose standards. Metrologia. 2009;46(2):S39. doi:10.1088/0026-1394/46/2/S04
Kawrakow I, Rogers DWO, Mainegra-hing E, Tessier F, Townson R, Walters BRB, EGSnrc: software for Monte Carlo simulation of ionizing radiation. Published online 2021. doi:10.4224/40001303
Agostinelli S, Allison J, Amako K, et al. Geant4-a simulation toolkit. Nucl Instrum Methods Phys Res A. 2003;506(3):250-303. doi:10.1016/S0168-9002(03)01368-8
JCGM. Evaluation of measurement data-Guide to the expression of uncertainty in measurement Évaluation des données de mesure-Guide pour l'expression de l'incertitude de mesure. Published online 2008. Accessed May 17, 2022. www.bipm.org
Ma CM, Coffey CW, DeWerd LA, et al. AAPM protocol for 40-300 kV x-ray beam dosimetry in radiotherapy and radiobiology. Med Phys. 2001;28(6):868-893. doi:10.1118/1.1374247
Seltzer SM, Fernandez-Varea JM, Andreo P, et al. Key data for ionizing-radiation dosimetry: measurement standards and applications, ICRU Report 90. Published online 2016.

Auteurs

Islam El Gamal (I)

Metrology Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
Department of Physics, Carleton University, Ottawa, Ontario, Canada.

Jean Dessureault (J)

Metrology Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.

Malcolm R McEwen (MR)

Metrology Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.

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Classifications MeSH