Latest developments on the mechanism of action of membrane disrupting peptides.
Antimicrobial peptides (AMPs)
Empirical models
Membrane disrupting peptides
Thermodynamic models
Journal
Biophysics reports
ISSN: 2364-3420
Titre abrégé: Biophys Rep
Pays: China
ID NLM: 101676603
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
01
08
2020
accepted:
19
03
2021
medline:
30
6
2021
pubmed:
30
6
2021
entrez:
8
6
2023
Statut:
ppublish
Résumé
Antimicrobial peptides (AMPs) are integral components of the innate immune defence system of all complex organisms including plants, insects, and mammals. They have wide range of antibacterial, antifungal, antiviral, and even anticancer activities, therefore AMPs are attractive candidates for developing novel therapeutic approaches. Cationic α-helical membrane disrupting peptides are perhaps the most widely studied subclass of AMPs due to their common fundamental characteristics that allow for detailed structure-function analysis and therefore offer a promising solution to the threat of multidrug resistant strains of bacteria. The majority of the studies of AMP activity focused on the biological and biophysical aspects of membrane disruption; the understanding of the molecular mechanism of action from the physicochemical point of view forms a relatively small subfield. This review will provide an overview of these works, focusing on the empirical and thermodynamic models of AMP action.
Identifiants
pubmed: 37287489
doi: 10.52601/bpr.2021.200037
pii: br-7-3-173
pmc: PMC10244799
doi:
Types de publication
Journal Article
Langues
eng
Pagination
173-184Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Sara Pandidan and Adam Mechler declare that they have no conflict of interest.
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