Biochemical and biophysical characterization of pathological aggregation of amyloid proteins.

Aggregation kinetics Amyloid protein Neurodegenerative diseases Parkinson’s disease Pathological fibrillation Transmission electron microscopy α-Synuclein

Journal

Biophysics reports
ISSN: 2364-3420
Titre abrégé: Biophys Rep
Pays: China
ID NLM: 101676603

Informations de publication

Date de publication:
28 Feb 2022
Historique:
received: 30 07 2021
accepted: 17 09 2021
medline: 28 2 2022
pubmed: 28 2 2022
entrez: 8 6 2023
Statut: ppublish

Résumé

Protein amyloid fibrillation, a process of liquid to solid phase transition, is involved in the pathogenesis of a variety of human diseases. Several amyloid proteins including α-synuclein (α-syn), Tau, amyloid β (Aβ) protein, and TAR DNA-binding protein 43 kDa (TDP-43) form pathological fibrils and deposit in patient brains of different neurodegenerative diseases (NDs) such as Parkinson's disease (PD), Alzheimer's disease (AD) and Amyotrophic lateral sclerosis (ALS). Preparation and characterization of amyloid fibrils

Identifiants

pubmed: 37287686
doi: 10.52601/bpr.2022.210032
pii: br-8-1-42
pmc: PMC10196661
doi:

Types de publication

Journal Article

Langues

eng

Pagination

42-54

Informations de copyright

© The Author(s) 2022.

Déclaration de conflit d'intérêts

Houfang Long, Shuyi Zeng, Yunpeng Sun and Cong Liu declare that they have no conflict of interest.

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Auteurs

Houfang Long (H)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Shuyi Zeng (S)

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China.
Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Yunpeng Sun (Y)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Cong Liu (C)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Classifications MeSH