Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy.
dexmedetomidine infusion
polysomnography
postoperative
sleep disordered
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
03
2023
accepted:
30
05
2023
medline:
9
6
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
epublish
Résumé
To examine whether nighttime dexmedetomidine infusion improved sleep quality in patients after laryngectomy. Thirty-five post-laryngectomy patients admitted to the intensive care unit (ICU) were randomly assigned to a 9-h (from 2100 h on surgery day to 0600 h the morning after laryngectomy) dexmedetomidine (0.3 μg/kg/h continuous infusion) or placebo group. Polysomnography results were monitored during the dexmedetomidine infusion period. The percentage of stage 2 non-rapid eye movement (stage N2) sleep was the primary outcome measure. Thirty-five patients (18 placebo group; 17 dexmedetomidine group) had complete polysomnogram recordings. The percentage of stage N3 sleep was significantly increased in the dexmedetomidine infusion group (from median 0% (0 to 0) in placebo group to 0% (interquartile range, 0 to 4) in dexmedetomidine group (difference, -2.32%; 95% CI, -4.19 to -0.443; P = 0.0167)). Infusion had no effect on total sleep time, stage N1 or N2 sleep percentages, or sleep efficiency. It decreased muscle tensity and snore non-rapid eye movement. Subjective sleep quality improved. Hypotension incidence increased in the dexmedetomidine group, but significant intervention was not required. Dexmedetomidine infusion improved overall patient sleep quality in the ICU after laryngectomy.
Identifiants
pubmed: 37287698
doi: 10.2147/DDDT.S413321
pii: 413321
pmc: PMC10243355
doi:
Substances chimiques
Dexmedetomidine
67VB76HONO
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1631-1640Informations de copyright
© 2023 Huang et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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