VEGF-A related SNPs: a cardiovascular context.
VEGF-A eQTLs
cardiovascular disease
genetic association
single nucleotide polymorphism
vascular endothelial growth factor
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
03
2023
accepted:
27
04
2023
medline:
8
6
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
epublish
Résumé
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Currently, cardiovascular disease risk algorithms play a role in primary prevention. However, this is complicated by a lack of powerfully predictive biomarkers that could be observed in individuals before the onset of overt symptoms. A key potential biomarker for heart disease is the vascular endothelial growth factor (VEGF-A), a molecule that plays a pivotal role in blood vessel formation. This molecule has a complex biological role in the cardiovascular system due to the processes it influences, and its production is impacted by various CVD risk factors. Research in different populations has shown single nucleotide polymorphisms (SNPs) may affect circulating VEGF-A plasma levels, with some variants associated with the development of CVDs, as well as CVD risk factors. This minireview aims to give an overview of the VEGF family, and of the SNPs reported to influence VEGF-A levels, cardiovascular disease, and other risk factors used in CVD risk assessments.
Identifiants
pubmed: 37288254
doi: 10.3389/fcvm.2023.1190513
pmc: PMC10242119
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1190513Informations de copyright
© 2023 Meza-Alvarado, Page, Mallard, Bromhead and Palmer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Rev Cardiovasc Med. 2022 Jan 11;23(1):8
pubmed: 35092200
J Am Coll Cardiol. 2020 Jun 9;75(22):2781-2784
pubmed: 32498805
Sci Rep. 2017 Dec;7(1):58
pubmed: 28246395
Curr Atheroscler Rep. 2016 Dec;18(12):78
pubmed: 27815829
BMC Med Genet. 2018 Jul 4;19(1):108
pubmed: 29973139
Cell. 2019 Mar 7;176(6):1248-1264
pubmed: 30849371
Genome Biol. 2005;6(2):209
pubmed: 15693956
J Biochem. 2013 Jan;153(1):13-9
pubmed: 23172303
Gene. 2013 Jun 1;521(2):217-21
pubmed: 23545315
Eur J Hum Genet. 2021 Feb;29(2):309-324
pubmed: 33110245
J Clin Invest. 1989 Nov;84(5):1470-8
pubmed: 2478587
PLoS Med. 2018 Mar 30;15(3):e1002546
pubmed: 29601582
Arch Med Sci. 2018 Oct;14(6):1361-1373
pubmed: 30393491
Front Immunol. 2019 Jun 25;10:1426
pubmed: 31293586
Glob Heart. 2017 Sep;12(3):247-257
pubmed: 28756179
J Clin Lab Anal. 2019 Feb;33(2):e22686
pubmed: 30350881
Nature. 2018 Jun;558(7708):73-79
pubmed: 29875488
J Diabetes Res. 2016;2016:1482194
pubmed: 26881237
J Physiol Sci. 2014 Jan;64(1):73-6
pubmed: 24097272
J Am Coll Cardiol. 2016 Dec 27;68(25):2797-2818
pubmed: 28007143
Tissue Antigens. 2011 Apr;77(4):291-7
pubmed: 21388351
J Diabetes Res. 2021 Jan 04;2021:7059139
pubmed: 33490285
Cell Mol Neurobiol. 2021 Aug;41(6):1217-1225
pubmed: 32506171
Redox Biol. 2017 Aug;12:18-34
pubmed: 28212521
Int J Mol Sci. 2021 May 20;22(10):
pubmed: 34065409
Nucleic Acids Res. 2013 Sep;41(17):7997-8010
pubmed: 23851566
PLoS One. 2021 Jul 14;16(7):e0254206
pubmed: 34260629
Adv Exp Med Biol. 2020;1228:169-179
pubmed: 32342457
N Engl J Med. 2016 Dec 15;375(24):2349-2358
pubmed: 27959714
Tumour Biol. 2018 Mar;40(3):1010428318766273
pubmed: 29584591
Cardiol Rev. 2014 May-Jun;22(3):147-51
pubmed: 24618929
J Neurol Sci. 2011 Sep 15;308(1-2):62-6
pubmed: 21705026
BMJ. 2016 May 16;353:i2416
pubmed: 27184143
Circ Res. 2017 Sep 1;121(6):677-694
pubmed: 28860318
Circ Res. 2016 Jan 8;118(1):83-94
pubmed: 26487741
J Cell Physiol. 2019 Aug;234(10):16812-16823
pubmed: 30790284
J Lipid Res. 2013 Feb;54(2):535-41
pubmed: 23204297
Circ Res. 2011 Aug 19;109(5):554-63
pubmed: 21757650
J Biol Chem. 1996 Mar 29;271(13):7788-95
pubmed: 8631822
Growth Factors. 2018 Dec;36(5-6):232-238
pubmed: 30689460
BMC Cancer. 2019 May 22;19(1):483
pubmed: 31117964
Nat Rev Mol Cell Biol. 2016 Oct;17(10):611-25
pubmed: 27461391
Eur Heart J. 2011 Aug;32(16):1977-85, 1985a, 1985b, 1985c
pubmed: 21398643
Medicine (Baltimore). 2016 May;95(19):e3413
pubmed: 27175642
Science. 1983 Feb 25;219(4587):983-5
pubmed: 6823562
Ann Clin Lab Sci. 2017 Mar;47(2):144-155
pubmed: 28442515
PLoS Genet. 2021 Mar 26;17(3):e1009427
pubmed: 33770080
Clin Biochem. 2013 Nov;46(16-17):1668-72
pubmed: 23880405
Cell. 2014 Jun 19;157(7):1605-18
pubmed: 24949972
Trends Cardiovasc Med. 2015 Apr;25(3):171-8
pubmed: 25453988
Heart Lung Circ. 2020 Apr;29(4):634-640
pubmed: 31974023
J Biol Chem. 2007 Sep 21;282(38):28045-56
pubmed: 17626017
J Am Heart Assoc. 2017 Aug 1;6(8):
pubmed: 28765276
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Clin Cardiol. 2021 Jun;44(6):771-779
pubmed: 34080689
PLoS Genet. 2016 Feb 24;12(2):e1005874
pubmed: 26910538
Growth Factors. 2018 Aug;36(3-4):153-163
pubmed: 30317903
Mol Vis. 2008 Jul 30;14:1382-7
pubmed: 18682813
Hum Mol Genet. 2014 Feb 1;23(3):782-95
pubmed: 24057673
Clin Neurol Neurosurg. 2020 Sep;196:106060
pubmed: 32645625
PLoS One. 2011 Feb 09;6(2):e16982
pubmed: 21347390
Cardiovasc Res. 2013 Sep 1;99(4):716-23
pubmed: 23756254
Int J Mol Sci. 2020 Jul 26;21(15):
pubmed: 32722551
Int J Mol Sci. 2018 Apr 23;19(4):
pubmed: 29690653
Science. 1989 Dec 8;246(4935):1306-9
pubmed: 2479986
Cancer Manag Res. 2019 May 01;11:3829-3845
pubmed: 31118800
Nature. 2021 Apr;592(7855):524-533
pubmed: 33883728
J Clin Med. 2020 Feb 08;9(2):
pubmed: 32046348
Curr Opin Cardiol. 2018 Sep;33(5):529-534
pubmed: 29979201
JACC Basic Transl Sci. 2021 Mar 22;6(3):287-304
pubmed: 33778213
Cytokine. 2013 Feb;61(2):602-7
pubmed: 23201487
Philos Trans R Soc Lond B Biol Sci. 2013 May 06;368(1620):20120362
pubmed: 23650636
Circ Res. 2016 Feb 19;118(4):564-78
pubmed: 26892958
Med Sci Monit. 2016 Jan 04;22:31-40
pubmed: 26726843
J Cell Biochem. 2019 Feb;120(2):1398-1406
pubmed: 30367505
Int J Environ Res Public Health. 2021 Jan 22;18(3):
pubmed: 33499313
Nat Rev Dis Primers. 2019 Aug 16;5(1):56
pubmed: 31420554
Front Cardiovasc Med. 2021 Aug 24;8:738325
pubmed: 34504884
Cell Oncol (Dordr). 2022 Apr;45(2):227-239
pubmed: 35303290
BMC Cardiovasc Disord. 2018 Aug 15;18(1):169
pubmed: 30111293
Int J Cardiol. 2016 Jul 15;215:105-9
pubmed: 27111169
Avicenna J Med Biotechnol. 2014 Oct;6(4):192-9
pubmed: 25414781
Biomolecules. 2021 Jan 12;11(1):
pubmed: 33445558
Cardiovasc Res. 2005 Feb 15;65(3):564-73
pubmed: 15664382
Circulation. 2022 Aug 23;146(8):e93-e118
pubmed: 35862132
Medicina (Kaunas). 2019 Aug 11;55(8):
pubmed: 31405227
J Biol Chem. 1991 Jun 25;266(18):11947-54
pubmed: 1711045
Science. 1989 Dec 8;246(4935):1309-12
pubmed: 2479987
Ann Transl Med. 2016 Jul;4(13):256
pubmed: 27500157
J Clin Neurosci. 2011 Apr;18(4):549-53
pubmed: 21316969
Heart Rhythm. 2014 Jan;11(1):76-82
pubmed: 24096169
J Inherit Metab Dis. 2015 Jul;38(4):753-63
pubmed: 25868665
Am J Med Sci. 2018 Jun;355(6):559-565
pubmed: 29891039
Biochem Pharmacol. 2013 Feb 15;85(4):531-40
pubmed: 23219526
Cancer Res. 2003 Feb 15;63(4):812-6
pubmed: 12591731
Cytokine. 2018 Jun;106:29-34
pubmed: 29533820
Trends Cardiovasc Med. 2020 Aug;30(6):328-334
pubmed: 31543237
Biomolecules. 2020 Dec 15;10(12):
pubmed: 33333800
Heart. 2016 Jul 15;102(14):1142-9
pubmed: 27126397
Int J Hypertens. 2020 Mar 19;2020:9185697
pubmed: 32257424
Cells. 2019 Mar 28;8(4):
pubmed: 30925751
Am J Ther. 2016 Nov/Dec;23(6):e1663-e1670
pubmed: 25738571
Blood Cells Mol Dis. 2015 Feb;54(2):139-43
pubmed: 25488616
Int J Dermatol. 2018 Oct;57(10):1201-1207
pubmed: 29984822