Factor XIII: More than just a fibrin stabilizer for the burn patient? A matched-pair analysis.
Burns
Coagulation
Factor XIII
Intensive care
Wound healing
Journal
JPRAS open
ISSN: 2352-5878
Titre abrégé: JPRAS Open
Pays: Netherlands
ID NLM: 101680420
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
04
02
2023
accepted:
15
04
2023
medline:
8
6
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
epublish
Résumé
Acquired factor XIII deficiency is an underestimated risk in patients with large surface burns, which potentially exposes these patients to prolonged bleeding and delayed wound healing if undetected. A retrospective matched-pair analysis of the burn registry of the Department of Plastic, Aesthetic, Hand, and Reconstructive Surgery of Hannover Medical School was performed from 2018 to 2023. A total of 18 patients were included. Acquired factor XIII deficiency was not statistically significant correlated with age, sex, or body mass index. Patients who developed acquired factor XIII deficiency had a significantly longer hospital stay (72.8 days) compared with those in the matched group (46.4 days), although burn depths, total body surface area, and Abbreviated Burn Severity Index were not statistically correlated with factor XIII deficiency. Little is known about acquired factor XIII deficiency in patients with burns. Factor XIII supplementation may improve hemostasis, wound healing, and general outcome while reducing the patient's exposure to blood products.
Sections du résumé
Background
UNASSIGNED
Acquired factor XIII deficiency is an underestimated risk in patients with large surface burns, which potentially exposes these patients to prolonged bleeding and delayed wound healing if undetected.
Methods
UNASSIGNED
A retrospective matched-pair analysis of the burn registry of the Department of Plastic, Aesthetic, Hand, and Reconstructive Surgery of Hannover Medical School was performed from 2018 to 2023.
Results
UNASSIGNED
A total of 18 patients were included. Acquired factor XIII deficiency was not statistically significant correlated with age, sex, or body mass index. Patients who developed acquired factor XIII deficiency had a significantly longer hospital stay (72.8 days) compared with those in the matched group (46.4 days), although burn depths, total body surface area, and Abbreviated Burn Severity Index were not statistically correlated with factor XIII deficiency.
Conclusions
UNASSIGNED
Little is known about acquired factor XIII deficiency in patients with burns. Factor XIII supplementation may improve hemostasis, wound healing, and general outcome while reducing the patient's exposure to blood products.
Identifiants
pubmed: 37288428
doi: 10.1016/j.jpra.2023.04.002
pii: S2352-5878(23)00012-8
pmc: PMC10242619
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-8Informations de copyright
© 2023 The Author(s).
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