The role of pain modulation pathway and related brain regions in pain.
ascending pain modulation
descending pain modulation
pain
pain matrix
Journal
Reviews in the neurosciences
ISSN: 2191-0200
Titre abrégé: Rev Neurosci
Pays: Germany
ID NLM: 8711016
Informations de publication
Date de publication:
15 12 2023
15 12 2023
Historique:
received:
25
03
2023
accepted:
18
05
2023
medline:
27
11
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
epublish
Résumé
Pain is a multifaceted process that encompasses unpleasant sensory and emotional experiences. The essence of the pain process is aversion, or perceived negative emotion. Central sensitization plays a significant role in initiating and perpetuating of chronic pain. Melzack proposed the concept of the "pain matrix", in which brain regions associated with pain form an interconnected network, rather than being controlled by a singular brain region. This review aims to investigate distinct brain regions involved in pain and their interconnections. In addition, it also sheds light on the reciprocal connectivity between the ascending and descending pathways that participate in pain modulation. We review the involvement of various brain areas during pain and focus on understanding the connections among them, which can contribute to a better understanding of pain mechanisms and provide opportunities for further research on therapies for improved pain management.
Identifiants
pubmed: 37288945
pii: revneuro-2023-0037
doi: 10.1515/revneuro-2023-0037
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
899-914Informations de copyright
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
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