Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract.
indocyanine green
intestine
multispectral optoacoustic tomography
optoacoustics
photoacoustics
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
21
04
2023
medline:
17
8
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Real-time imaging and functional assessment of the intestinal tract and its transit pose a significant challenge to conventional clinical diagnostic methods. Multispectral optoacoustic tomography (MSOT), a molecular-sensitive imaging technology, offers the potential to visualize endogenous and exogenous chromophores in deep tissue. Herein, a novel approach using the orally administered clinical-approved fluorescent dye indocyanine green (ICG) for bedside, non-ionizing evaluation of gastrointestinal passage is presented. The authors are able to show the detectability and stability of ICG in phantom experiments. Furthermore, ten healthy subjects underwent MSOT imaging at multiple time points over eight hours after ingestion of a standardized meal with and without ICG. ICG signals can be visualized and quantified in different intestinal segments, while its excretion is confirmed by fluorescent imaging of stool samples. These findings indicate that contrast-enhanced MSOT (CE-MSOT) provides a translatable real-time imaging approach for functional assessment of the gastrointestinal tract.
Identifiants
pubmed: 37289088
doi: 10.1002/advs.202302562
pmc: PMC10427354
doi:
Substances chimiques
Indocyanine Green
IX6J1063HV
Fluorescent Dyes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2302562Subventions
Organisme : Interdisciplinary Center for Clinical Research
ID : J89
Organisme : University Hospital of the Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg
Organisme : CRUK
ID : C9545/A29580
Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
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