Multiscale model of the different modes of cancer cell invasion.
Journal
Bioinformatics (Oxford, England)
ISSN: 1367-4811
Titre abrégé: Bioinformatics
Pays: England
ID NLM: 9808944
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
received:
14
11
2022
revised:
25
05
2023
accepted:
07
06
2023
medline:
28
6
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Mathematical models of biological processes altered in cancer are built using the knowledge of complex networks of signaling pathways, detailing the molecular regulations inside different cell types, such as tumor cells, immune and other stromal cells. If these models mainly focus on intracellular information, they often omit a description of the spatial organization among cells and their interactions, and with the tumoral microenvironment. We present here a model of tumor cell invasion simulated with PhysiBoSS, a multiscale framework, which combines agent-based modeling and continuous time Markov processes applied on Boolean network models. With this model, we aim to study the different modes of cell migration and to predict means to block it by considering not only spatial information obtained from the agent-based simulation but also intracellular regulation obtained from the Boolean model. Our multiscale model integrates the impact of gene mutations with the perturbation of the environmental conditions and allows the visualization of the results with 2D and 3D representations. The model successfully reproduces single and collective migration processes and is validated on published experiments on cell invasion. In silico experiments are suggested to search for possible targets that can block the more invasive tumoral phenotypes. https://github.com/sysbio-curie/Invasion_model_PhysiBoSS.
Identifiants
pubmed: 37289551
pii: 7192171
doi: 10.1093/bioinformatics/btad374
pmc: PMC10293590
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press.
Références
Bioinformatics. 2017 Jul 15;33(14):2226-2228
pubmed: 28881959
Adv Exp Med Biol. 2017;994:229-245
pubmed: 28560677
Sci Data. 2018 Oct 02;5:180198
pubmed: 30277482
Cell. 2011 Nov 23;147(5):992-1009
pubmed: 22118458
Curr Opin Cell Biol. 2011 Oct;23(5):597-606
pubmed: 21550788
Oncogene. 2019 May;38(21):4075-4094
pubmed: 30696956
PLoS Comput Biol. 2021 Feb 26;17(2):e1008764
pubmed: 33635856
Nat Cell Biol. 2020 Sep;22(9):1103-1115
pubmed: 32839548
Dev Dyn. 2018 Mar;247(3):368-381
pubmed: 28758355
Nat Rev Cancer. 2022 Mar;22(3):157-173
pubmed: 35013601
Oncotarget. 2014 Mar 15;5(5):1279-89
pubmed: 24658133
Am J Transl Res. 2019 Sep 15;11(9):5301-5312
pubmed: 31632511
Nat Rev Cancer. 2021 Sep;21(9):592-604
pubmed: 34239104
Mol Biol Cell. 2006 Mar;17(3):1261-72
pubmed: 16371504
JCO Clin Cancer Inform. 2019 Feb;3:1-13
pubmed: 30715927
Biosystems. 2019 Aug;182:1-7
pubmed: 31100305
J R Soc Interface. 2017 Sep;14(134):
pubmed: 28931635
Cell Syst. 2019 Aug 28;9(2):109-127
pubmed: 31465728
J Epidemiol Glob Health. 2019 Dec;9(4):217-222
pubmed: 31854162
Biophys J. 2005 Dec;89(6):3884-94
pubmed: 16199495
Annu Rev Biomed Eng. 2011 Aug 15;13:127-55
pubmed: 21529163
Cancer Res. 2010 Nov 1;70(21):8517-25
pubmed: 20947521
J Cell Sci. 2020 Apr 28;133(8):
pubmed: 32193332
Cell Commun Signal. 2010 Sep 07;8:23
pubmed: 20822528
Math Med Biol. 2005 Jun;22(2):163-86
pubmed: 15781426
BMC Syst Biol. 2012 Aug 29;6:116
pubmed: 22932419
Elife. 2022 Feb 15;11:
pubmed: 35164900
Br J Cancer. 2021 Jul;125(2):164-175
pubmed: 33824479
Nat Commun. 2019 Oct 25;10(1):4886
pubmed: 31653854
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Sci Rep. 2021 May 13;11(1):10291
pubmed: 33986306
Nat Rev Cancer. 2013 Jan;13(1):11-26
pubmed: 23258168
J Cell Biol. 2013 Jun 24;201(7):1069-84
pubmed: 23798731
PLoS Comput Biol. 2015 Nov 03;11(11):e1004571
pubmed: 26528548
Front Cell Dev Biol. 2020 Jan 31;8:25
pubmed: 32083079
Mol Cancer Res. 2011 Dec;9(12):1608-20
pubmed: 21840933
Bioinformatics. 2019 Apr 1;35(7):1188-1196
pubmed: 30169736
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
Front Physiol. 2019 Aug 13;10:790
pubmed: 31456688
Elife. 2020 Sep 23;9:
pubmed: 32965214
J Cell Biol. 2010 Jan 11;188(1):11-9
pubmed: 19951899
Cancer Res. 2020 Jun 1;80(11):2407-2420
pubmed: 32217696
PLoS One. 2018 Oct 4;13(10):e0204865
pubmed: 30286133
J Oncol. 2019 Oct 31;2019:2403483
pubmed: 31814825
PLoS Comput Biol. 2018 Feb 23;14(2):e1005991
pubmed: 29474446
J Theor Biol. 2019 Nov 7;480:43-55
pubmed: 31374282
Comput Struct Biotechnol J. 2020 Mar 10;18:571-582
pubmed: 32257043
Cell Adh Migr. 2014;8(3):273-9
pubmed: 24713806
Bull Math Biol. 2019 Jun;81(6):1965-2010
pubmed: 30903592
Cell. 2021 Sep 30;184(20):5230-5246.e22
pubmed: 34551315
Matrix Biol. 2015 Sep;47:54-65
pubmed: 25960420
Oncogene. 2021 Jun;40(23):4019-4032
pubmed: 34012098